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Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis

Insulin-induced genes (INSIGs) encode endoplasmic reticulum–resident proteins that regulate intracellular cholesterol metabolism. Oxysterols are oxygenated derivatives of cholesterol, some of which orchestrate lipid metabolism via interaction with INSIGs. Recently, it was reported that expression of...

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Detalles Bibliográficos
Autores principales:	Watanabe, Yuichi, Sasaki, Takashi, Miyoshi, Shoko, Shimizu, Makoto, Yamauchi, Yoshio, Sato, Ryuichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363831/ https://www.ncbi.nlm.nih.gov/pubmed/34298014 http://dx.doi.org/10.1016/j.jbc.2021.100989

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