Interdomain flexibility and interfacial integrity of β-lactamase inhibitory protein (BLIP) modulate its binding to class A β-lactamases

β-Lactamase inhibitory protein (BLIP) consists of a tandem repeat of αβ domains conjugated by an interdomain loop and can effectively bind and inactivate class A β-lactamases, which are responsible for resistance of bacteria to β-lactam antibiotics. The varied ability of BLIP to bind different β-lac...

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Detalles Bibliográficos
Autores principales: Huang, Liwen, So, Pui-Kin, Chen, Yu Wai, Leung, Yun-Chung, Yao, Zhong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363833/
https://www.ncbi.nlm.nih.gov/pubmed/34302811
http://dx.doi.org/10.1016/j.jbc.2021.100980

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