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HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression

Mantle cell lymphoma (MCL) is an especially aggressive and highly heterogeneous mature B-cell lymphoma. Heat shock protein 90 (HSP90) is considered an attractive therapeutic target in a variety of cancers, including MCL, but no HSP90 inhibitors have succeeded in the clinical trials to date. Explorin...

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Detalles Bibliográficos
Autores principales:	Liu, Hanqing, Lu, Ziwen, Shi, Xiaofeng, Liu, Lanlan, Zhang, Peishan, Golemis, Erica A., Tu, Zhigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363837/ https://www.ncbi.nlm.nih.gov/pubmed/34302809 http://dx.doi.org/10.1016/j.jbc.2021.100996

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