Cargando…
The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018
OBJECTIVE: To describe point prevalence of knee symptoms, radiographic knee osteoarthritis (rKOA), severe rKOA, and symptomatic rKOA at four time points in the longitudinal, population‐based Johnston County Osteoarthritis Project (JoCo OA). METHODS: Data were from 2573 JoCo OA participants with up t...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363850/ https://www.ncbi.nlm.nih.gov/pubmed/34245232 http://dx.doi.org/10.1002/acr2.11295 |
_version_ | 1783738421220474880 |
---|---|
author | Nelson, Amanda E. Hu, David Arbeeva, Liubov Alvarez, Carolina Cleveland, Rebecca J. Schwartz, Todd A. Murphy, Louise B. Helmick, Charles G. Callahan, Leigh F. Renner, Jordan B. Jordan, Joanne M. Golightly, Yvonne M. |
author_facet | Nelson, Amanda E. Hu, David Arbeeva, Liubov Alvarez, Carolina Cleveland, Rebecca J. Schwartz, Todd A. Murphy, Louise B. Helmick, Charles G. Callahan, Leigh F. Renner, Jordan B. Jordan, Joanne M. Golightly, Yvonne M. |
author_sort | Nelson, Amanda E. |
collection | PubMed |
description | OBJECTIVE: To describe point prevalence of knee symptoms, radiographic knee osteoarthritis (rKOA), severe rKOA, and symptomatic rKOA at four time points in the longitudinal, population‐based Johnston County Osteoarthritis Project (JoCo OA). METHODS: Data were from 2573 JoCo OA participants with up to 18 years of follow‐up (1999‐2018) and standardized fixed‐flexion knee radiographs read by a single, reliable expert musculoskeletal radiologist. The four outcomes were 1) self‐reported knee symptoms, defined by “On most days, do you have pain, aching, or stiffness in your right/left knee?”; 2) rKOA, defined as a Kellgren‐Lawrence grade (KLG) of 2 to 4); 3) severe rKOA, defined as a KLG of 3 or 4; and 4) symptomatic rKOA, defined as both symptoms and rKOA in the same joint. Weighted prevalence estimates and 95% confidence intervals (CIs) were generated overall and by age group, sex, race, and body mass index (BMI). RESULTS: Most recently (2017‐2018, T4), the overall prevalence (percentage) of knee symptoms, rKOA, severe rKOA, and symptomatic rKOA was 41% (95% CI: 35‐47%), 61% (95% CI: 56‐67%), 35% (95% CI: 30‐40%), and 30% (95% CI: 24‐35%), respectively. From time point T1 to T4, prevalence increased for rKOA, severe rKOA, and symptomatic rKOA but not for knee symptoms. The prevalence of both severe rKOA (17‐39%) and symptomatic rKOA (23‐30%) was consistently higher among women. The prevalence of all outcomes was higher among those with higher BMI and among Black participants at all time points, particularly rKOA (35‐69%) and severe rKOA (22‐46%). CONCLUSION: These updated estimates demonstrate a large and increasing burden of knee OA, particularly among women and Black individuals. |
format | Online Article Text |
id | pubmed-8363850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83638502021-08-23 The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 Nelson, Amanda E. Hu, David Arbeeva, Liubov Alvarez, Carolina Cleveland, Rebecca J. Schwartz, Todd A. Murphy, Louise B. Helmick, Charles G. Callahan, Leigh F. Renner, Jordan B. Jordan, Joanne M. Golightly, Yvonne M. ACR Open Rheumatol Original Articles OBJECTIVE: To describe point prevalence of knee symptoms, radiographic knee osteoarthritis (rKOA), severe rKOA, and symptomatic rKOA at four time points in the longitudinal, population‐based Johnston County Osteoarthritis Project (JoCo OA). METHODS: Data were from 2573 JoCo OA participants with up to 18 years of follow‐up (1999‐2018) and standardized fixed‐flexion knee radiographs read by a single, reliable expert musculoskeletal radiologist. The four outcomes were 1) self‐reported knee symptoms, defined by “On most days, do you have pain, aching, or stiffness in your right/left knee?”; 2) rKOA, defined as a Kellgren‐Lawrence grade (KLG) of 2 to 4); 3) severe rKOA, defined as a KLG of 3 or 4; and 4) symptomatic rKOA, defined as both symptoms and rKOA in the same joint. Weighted prevalence estimates and 95% confidence intervals (CIs) were generated overall and by age group, sex, race, and body mass index (BMI). RESULTS: Most recently (2017‐2018, T4), the overall prevalence (percentage) of knee symptoms, rKOA, severe rKOA, and symptomatic rKOA was 41% (95% CI: 35‐47%), 61% (95% CI: 56‐67%), 35% (95% CI: 30‐40%), and 30% (95% CI: 24‐35%), respectively. From time point T1 to T4, prevalence increased for rKOA, severe rKOA, and symptomatic rKOA but not for knee symptoms. The prevalence of both severe rKOA (17‐39%) and symptomatic rKOA (23‐30%) was consistently higher among women. The prevalence of all outcomes was higher among those with higher BMI and among Black participants at all time points, particularly rKOA (35‐69%) and severe rKOA (22‐46%). CONCLUSION: These updated estimates demonstrate a large and increasing burden of knee OA, particularly among women and Black individuals. John Wiley and Sons Inc. 2021-07-10 /pmc/articles/PMC8363850/ /pubmed/34245232 http://dx.doi.org/10.1002/acr2.11295 Text en © 2021 The Authors. ACR Open Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Nelson, Amanda E. Hu, David Arbeeva, Liubov Alvarez, Carolina Cleveland, Rebecca J. Schwartz, Todd A. Murphy, Louise B. Helmick, Charles G. Callahan, Leigh F. Renner, Jordan B. Jordan, Joanne M. Golightly, Yvonne M. The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title | The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title_full | The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title_fullStr | The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title_full_unstemmed | The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title_short | The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999‐2018 |
title_sort | prevalence of knee symptoms, radiographic, and symptomatic osteoarthritis at four time points: the johnston county osteoarthritis project, 1999‐2018 |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363850/ https://www.ncbi.nlm.nih.gov/pubmed/34245232 http://dx.doi.org/10.1002/acr2.11295 |
work_keys_str_mv | AT nelsonamandae theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT hudavid theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT arbeevaliubov theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT alvarezcarolina theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT clevelandrebeccaj theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT schwartztodda theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT murphylouiseb theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT helmickcharlesg theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT callahanleighf theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT rennerjordanb theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT jordanjoannem theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT golightlyyvonnem theprevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT nelsonamandae prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT hudavid prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT arbeevaliubov prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT alvarezcarolina prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT clevelandrebeccaj prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT schwartztodda prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT murphylouiseb prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT helmickcharlesg prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT callahanleighf prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT rennerjordanb prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT jordanjoannem prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 AT golightlyyvonnem prevalenceofkneesymptomsradiographicandsymptomaticosteoarthritisatfourtimepointsthejohnstoncountyosteoarthritisproject19992018 |