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Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis

OBJECTIVE: During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of this work was to investigate the inhibiting role of a JAK-inhibitor, tofacitinib, on the angiogenic mechanisms occurrin...

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Detalles Bibliográficos
Autores principales:	Di Benedetto, Paola, Ruscitti, Piero, Berardicurti, Onorina, Panzera, Noemi, Grazia, Nicolò, Di Vito Nolfi, Mauro, Di Francesco, Barbara, Navarini, Luca, Maurizi, Antonio, Rucci, Nadia, Teti, Anna Maria, Zazzeroni, Francesca, Guggino, Giuliana, Ciccia, Francesco, Dolo, Vincenza, Alesse, Edoardo, Cipriani, Paola, Giacomelli, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364029/ https://www.ncbi.nlm.nih.gov/pubmed/34391476 http://dx.doi.org/10.1186/s13075-021-02587-8

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