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Paradoxical effects of arsenic in the lungs
High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364060/ https://www.ncbi.nlm.nih.gov/pubmed/34388980 http://dx.doi.org/10.1186/s12199-021-00998-2 |
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author | Ren, Caixia Zhou, Yang Liu, Wenwen Wang, Qi |
author_facet | Ren, Caixia Zhou, Yang Liu, Wenwen Wang, Qi |
author_sort | Ren, Caixia |
collection | PubMed |
description | High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose-dependent manner. Arsenic trioxide (ATO) is recognized as a chemotherapeutic drug for acute promyelocytic leukemia (APL), also having a significant effect on lung cancer. The anti-lung cancer mechanisms of ATO include inhibition of proliferation, promotion of apoptosis, anti-angiogenesis, and inhibition of tumor metastasis. In this review, we summarized the role of arsenic in lung disease from both pathogenic and therapeutic perspectives. Understanding the paradoxical effects of arsenic in the lungs may provide some ideas for further research on the occurrence and treatment of lung diseases. |
format | Online Article Text |
id | pubmed-8364060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83640602021-08-17 Paradoxical effects of arsenic in the lungs Ren, Caixia Zhou, Yang Liu, Wenwen Wang, Qi Environ Health Prev Med Review Article High levels (> 100 ug/L) of arsenic are known to cause lung cancer; however, whether low (≤ 10 ug/L) and medium (10 to 100 ug/L) doses of arsenic will cause lung cancer or other lung diseases, and whether arsenic has dose-dependent or threshold effects, remains unknown. Summarizing the results of previous studies, we infer that low- and medium-concentration arsenic cause lung diseases in a dose-dependent manner. Arsenic trioxide (ATO) is recognized as a chemotherapeutic drug for acute promyelocytic leukemia (APL), also having a significant effect on lung cancer. The anti-lung cancer mechanisms of ATO include inhibition of proliferation, promotion of apoptosis, anti-angiogenesis, and inhibition of tumor metastasis. In this review, we summarized the role of arsenic in lung disease from both pathogenic and therapeutic perspectives. Understanding the paradoxical effects of arsenic in the lungs may provide some ideas for further research on the occurrence and treatment of lung diseases. BioMed Central 2021-08-13 2021 /pmc/articles/PMC8364060/ /pubmed/34388980 http://dx.doi.org/10.1186/s12199-021-00998-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Article Ren, Caixia Zhou, Yang Liu, Wenwen Wang, Qi Paradoxical effects of arsenic in the lungs |
title | Paradoxical effects of arsenic in the lungs |
title_full | Paradoxical effects of arsenic in the lungs |
title_fullStr | Paradoxical effects of arsenic in the lungs |
title_full_unstemmed | Paradoxical effects of arsenic in the lungs |
title_short | Paradoxical effects of arsenic in the lungs |
title_sort | paradoxical effects of arsenic in the lungs |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364060/ https://www.ncbi.nlm.nih.gov/pubmed/34388980 http://dx.doi.org/10.1186/s12199-021-00998-2 |
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