Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism

Lysosomes degrade excess or damaged cellular components and recycle their building blocks through membrane transporters. They also act as nutrient-sensing signaling hubs to coordinate cell responses. The membrane protein PQ-loop repeat-containing protein 2 (PQLC2; “picklock two”) is implicated in bo...

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Detalles Bibliográficos
Autores principales: Leray, Xavier, Conti, Rossella, Li, Yan, Debacker, Cécile, Castelli, Florence, Fenaille, François, Zdebik, Anselm A., Pusch, Michael, Gasnier, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364130/
https://www.ncbi.nlm.nih.gov/pubmed/34344826
http://dx.doi.org/10.1073/pnas.2025315118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364130/
https://www.ncbi.nlm.nih.gov/pubmed/34344826
http://dx.doi.org/10.1073/pnas.2025315118

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