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Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism
Lysosomes degrade excess or damaged cellular components and recycle their building blocks through membrane transporters. They also act as nutrient-sensing signaling hubs to coordinate cell responses. The membrane protein PQ-loop repeat-containing protein 2 (PQLC2; “picklock two”) is implicated in bo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364130/ https://www.ncbi.nlm.nih.gov/pubmed/34344826 http://dx.doi.org/10.1073/pnas.2025315118 |