Rapid interrogation of cancer cell of origin through CRISPR editing

The increasing complexity of different cell types revealed by single-cell analysis of tissues presents challenges in efficiently elucidating their functions. Here we show, using prostate as a model tissue, that primary organoids and freshly isolated epithelial cells can be CRISPR edited ex vivo usin...

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Detalles Bibliográficos
Autores principales: Feng, Weiran, Cao, Zhen, Lim, Pei Xin, Zhao, Huiyong, Luo, Hanzhi, Mao, Ninghui, Lee, Young Sun, Rivera, Aura Agudelo, Choi, Danielle, Wu, Chao, Han, Teng, Romero, Rodrigo, de Stanchina, Elisa, Carver, Brett S., Wang, Qiao, Jasin, Maria, Sawyers, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364185/
https://www.ncbi.nlm.nih.gov/pubmed/34353917
http://dx.doi.org/10.1073/pnas.2110344118

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