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p53-dependent apoptosis is essential for the antitumor effect of paclitaxel response to DNA damage in papillary thyroid carcinoma

A functional p53 protein plays an important role in killing tumor cells. Previous studies showed that chemotherapeutic drug, paclitaxel (PTX), showed anti-tumor activity through inducing G2/M arrest and apoptosis by targeting microtubules in tumor cells. However, PTX was not sensitive to p53-inactiv...

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Detalles Bibliográficos
Autores principales:	Wu, Wenshuang, Wei, Tao, Li, ZhiHui, Zhu, Jingqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364467/ https://www.ncbi.nlm.nih.gov/pubmed/34400889 http://dx.doi.org/10.7150/ijms.61944

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