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Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders
PURPOSE: Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery. METHODS: Patients with healthy ocular surface, subclinical, or mild dry eye we...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364531/ https://www.ncbi.nlm.nih.gov/pubmed/33956256 http://dx.doi.org/10.1007/s10792-021-01869-z |
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author | Cagini, Carlo Torroni, Giovanni Mariniello, Marco Di Lascio, Giampiero Martone, Gianluca Balestrazzi, Angelo |
author_facet | Cagini, Carlo Torroni, Giovanni Mariniello, Marco Di Lascio, Giampiero Martone, Gianluca Balestrazzi, Angelo |
author_sort | Cagini, Carlo |
collection | PubMed |
description | PURPOSE: Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery. METHODS: Patients with healthy ocular surface, subclinical, or mild dry eye were enrolled. Tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and ocular surface disease (OSDI) evaluation were performed pre-operatively and at two and four weeks after surgery. Patients were assigned to receive trehalose/sodium hyaluronate eye drops b.i.d (Group A), or 0.9% unpreserved sodium chloride eye drops b.i.d for 4 weeks (Group B). RESULTS: One hundred and thirty-five patients were randomised, 66 patients in Group A (73.2 ± 4.5 years) and 69 patients in Group B (74.3 ± 3.8 years), 60.8% females. Fifteen patients (8 Group A) were lost at follow-up. Pre-operatively, no between-group differences were observed, and TBUT increased in Group A between the pre-operative and 2 and 4 week evaluations and was higher in group A than in Group B at 4 weeks. Schirmer test and CFS showed an improvement only in Group A four weeks post-operatively. In Group A an improvement was observed after two and four weeks in foreign body and puncture sensation, whilst a difference in blinking discomfort was observed after four weeks. In Group B we observed an improvement in puncture sensation two and four weeks after surgery. Mean OSDI scores differences between the two groups were significant at four weeks. CONCLUSIONS: Trehalose/sodium hyaluronate eye drops were effective in reducing signs and symptoms of dry eye and improving tear film stability |
format | Online Article Text |
id | pubmed-8364531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-83645312021-08-19 Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders Cagini, Carlo Torroni, Giovanni Mariniello, Marco Di Lascio, Giampiero Martone, Gianluca Balestrazzi, Angelo Int Ophthalmol Original Paper PURPOSE: Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery. METHODS: Patients with healthy ocular surface, subclinical, or mild dry eye were enrolled. Tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and ocular surface disease (OSDI) evaluation were performed pre-operatively and at two and four weeks after surgery. Patients were assigned to receive trehalose/sodium hyaluronate eye drops b.i.d (Group A), or 0.9% unpreserved sodium chloride eye drops b.i.d for 4 weeks (Group B). RESULTS: One hundred and thirty-five patients were randomised, 66 patients in Group A (73.2 ± 4.5 years) and 69 patients in Group B (74.3 ± 3.8 years), 60.8% females. Fifteen patients (8 Group A) were lost at follow-up. Pre-operatively, no between-group differences were observed, and TBUT increased in Group A between the pre-operative and 2 and 4 week evaluations and was higher in group A than in Group B at 4 weeks. Schirmer test and CFS showed an improvement only in Group A four weeks post-operatively. In Group A an improvement was observed after two and four weeks in foreign body and puncture sensation, whilst a difference in blinking discomfort was observed after four weeks. In Group B we observed an improvement in puncture sensation two and four weeks after surgery. Mean OSDI scores differences between the two groups were significant at four weeks. CONCLUSIONS: Trehalose/sodium hyaluronate eye drops were effective in reducing signs and symptoms of dry eye and improving tear film stability Springer Netherlands 2021-05-06 2021 /pmc/articles/PMC8364531/ /pubmed/33956256 http://dx.doi.org/10.1007/s10792-021-01869-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Cagini, Carlo Torroni, Giovanni Mariniello, Marco Di Lascio, Giampiero Martone, Gianluca Balestrazzi, Angelo Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title_full | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title_fullStr | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title_full_unstemmed | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title_short | Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
title_sort | trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364531/ https://www.ncbi.nlm.nih.gov/pubmed/33956256 http://dx.doi.org/10.1007/s10792-021-01869-z |
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