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Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging

X-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently neede...

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Autores principales: Xie, Jun, Zhou, Zonglang, Ma, Sihan, Luo, Xian, Liu, Jiajing, Wang, Shengyu, Chen, Yuqiang, Yan, Jianghua, Luo, Fanghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364619/
https://www.ncbi.nlm.nih.gov/pubmed/34390420
http://dx.doi.org/10.1186/s11671-021-03591-2
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author Xie, Jun
Zhou, Zonglang
Ma, Sihan
Luo, Xian
Liu, Jiajing
Wang, Shengyu
Chen, Yuqiang
Yan, Jianghua
Luo, Fanghong
author_facet Xie, Jun
Zhou, Zonglang
Ma, Sihan
Luo, Xian
Liu, Jiajing
Wang, Shengyu
Chen, Yuqiang
Yan, Jianghua
Luo, Fanghong
author_sort Xie, Jun
collection PubMed
description X-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number (Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm(2) kg(−1) at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF(3): Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF(3): Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF(3): Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF(3): Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF(3): Ln@PVP NPs. Finally, the BiF(3): Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF(3): Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging.
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spelling pubmed-83646192021-08-30 Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging Xie, Jun Zhou, Zonglang Ma, Sihan Luo, Xian Liu, Jiajing Wang, Shengyu Chen, Yuqiang Yan, Jianghua Luo, Fanghong Nanoscale Res Lett Nano Express X-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number (Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm(2) kg(−1) at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF(3): Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF(3): Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF(3): Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF(3): Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF(3): Ln@PVP NPs. Finally, the BiF(3): Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF(3): Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging. Springer US 2021-08-14 /pmc/articles/PMC8364619/ /pubmed/34390420 http://dx.doi.org/10.1186/s11671-021-03591-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Nano Express
Xie, Jun
Zhou, Zonglang
Ma, Sihan
Luo, Xian
Liu, Jiajing
Wang, Shengyu
Chen, Yuqiang
Yan, Jianghua
Luo, Fanghong
Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title_full Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title_fullStr Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title_full_unstemmed Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title_short Facile Fabrication of BiF(3): Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging
title_sort facile fabrication of bif(3): ln (ln = gd, yb, er)@pvp nanoparticles for high-efficiency computed tomography imaging
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364619/
https://www.ncbi.nlm.nih.gov/pubmed/34390420
http://dx.doi.org/10.1186/s11671-021-03591-2
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