Cargando…
In vivo inducing collagen regeneration of biodegradable polymer microspheres
Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Herein, eight biodegradable polymers with different molecular weig...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364987/ https://www.ncbi.nlm.nih.gov/pubmed/34408912 http://dx.doi.org/10.1093/rb/rbab042 |
_version_ | 1783738621806772224 |
---|---|
author | Zhang, Yixin Liang, Hanwen Luo, Qian Chen, Jianlin Zhao, Nan Gao, Wenxia Pu, Yuji He, Bin Xie, Jing |
author_facet | Zhang, Yixin Liang, Hanwen Luo, Qian Chen, Jianlin Zhao, Nan Gao, Wenxia Pu, Yuji He, Bin Xie, Jing |
author_sort | Zhang, Yixin |
collection | PubMed |
description | Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Herein, eight biodegradable polymers with different molecular weights, chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications. Polymer microspheres with 20–100 μm were prepared. The in vitro degradation study showed that poly (L-lactic-co-glycolic acid) 75/25 microspheres degraded the fastest, whereas poly (L-lactic acid) (PLLA) microspheres with intrinsic viscosity of 6.89 ([η] = 6.89) with the highest molecular weight showed the slowest degradation rate. After these microspheres were fabricated dermal fillers according to the formula of Sculptra(®), they were injected subcutaneously into the back skin of rabbits. In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres. The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time. PLLA ([η] = 3.80) microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect. These properties of size, morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. |
format | Online Article Text |
id | pubmed-8364987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83649872021-08-17 In vivo inducing collagen regeneration of biodegradable polymer microspheres Zhang, Yixin Liang, Hanwen Luo, Qian Chen, Jianlin Zhao, Nan Gao, Wenxia Pu, Yuji He, Bin Xie, Jing Regen Biomater Research Article Biodegradable polymer particles have been used as dermal fillers for pre-clinical and clinical trials. The impact of material properties of polymers is very important to develop products for aesthetic medicine such as dermal fillers. Herein, eight biodegradable polymers with different molecular weights, chemical compositions or hydrophilic-hydrophobic properties were prepared and characterized for systematical study for aesthetic medicine applications. Polymer microspheres with 20–100 μm were prepared. The in vitro degradation study showed that poly (L-lactic-co-glycolic acid) 75/25 microspheres degraded the fastest, whereas poly (L-lactic acid) (PLLA) microspheres with intrinsic viscosity of 6.89 ([η] = 6.89) with the highest molecular weight showed the slowest degradation rate. After these microspheres were fabricated dermal fillers according to the formula of Sculptra(®), they were injected subcutaneously into the back skin of rabbits. In vivo results demonstrated that the degradation rate of microspheres strongly correlated with the foreign body reaction and collagen regeneration was induced by microspheres. The microspheres with faster degradation rate induced inflammatory response and the collagen regeneration maintained in shorter time. PLLA ([η] = 3.80) microsphere with a moderate molecular weight and degradation rate could strongly regenerate Type I and III collagen to maintain a long-term aesthetic medicine effect. These properties of size, morphology and degradation behavior would influence the foreign body reaction and collagen regeneration. Oxford University Press 2021-07-15 /pmc/articles/PMC8364987/ /pubmed/34408912 http://dx.doi.org/10.1093/rb/rbab042 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Yixin Liang, Hanwen Luo, Qian Chen, Jianlin Zhao, Nan Gao, Wenxia Pu, Yuji He, Bin Xie, Jing In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title | In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title_full | In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title_fullStr | In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title_full_unstemmed | In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title_short | In vivo inducing collagen regeneration of biodegradable polymer microspheres |
title_sort | in vivo inducing collagen regeneration of biodegradable polymer microspheres |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364987/ https://www.ncbi.nlm.nih.gov/pubmed/34408912 http://dx.doi.org/10.1093/rb/rbab042 |
work_keys_str_mv | AT zhangyixin invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT lianghanwen invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT luoqian invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT chenjianlin invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT zhaonan invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT gaowenxia invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT puyuji invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT hebin invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres AT xiejing invivoinducingcollagenregenerationofbiodegradablepolymermicrospheres |