Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19

Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRS...

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Autores principales: Shafiee, Sepehr, Cegolon, Luca, Khafaei, Mostafa, Gholami, Nasrin, Zhao, Shi, Khalesi, Nasrin, Moosavian, Hamidreza, Fathi, Saeid, Izadi, Morteza, Ghadian, Alireza, Javanbakht, Mohammad, Javanbakht, Amin, Akhavan-Sigari, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365127/
https://www.ncbi.nlm.nih.gov/pubmed/34399734
http://dx.doi.org/10.1186/s12935-021-02129-x
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author Shafiee, Sepehr
Cegolon, Luca
Khafaei, Mostafa
Gholami, Nasrin
Zhao, Shi
Khalesi, Nasrin
Moosavian, Hamidreza
Fathi, Saeid
Izadi, Morteza
Ghadian, Alireza
Javanbakht, Mohammad
Javanbakht, Amin
Akhavan-Sigari, Reza
author_facet Shafiee, Sepehr
Cegolon, Luca
Khafaei, Mostafa
Gholami, Nasrin
Zhao, Shi
Khalesi, Nasrin
Moosavian, Hamidreza
Fathi, Saeid
Izadi, Morteza
Ghadian, Alireza
Javanbakht, Mohammad
Javanbakht, Amin
Akhavan-Sigari, Reza
author_sort Shafiee, Sepehr
collection PubMed
description Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies.
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spelling pubmed-83651272021-08-16 Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19 Shafiee, Sepehr Cegolon, Luca Khafaei, Mostafa Gholami, Nasrin Zhao, Shi Khalesi, Nasrin Moosavian, Hamidreza Fathi, Saeid Izadi, Morteza Ghadian, Alireza Javanbakht, Mohammad Javanbakht, Amin Akhavan-Sigari, Reza Cancer Cell Int Review Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies. BioMed Central 2021-08-16 /pmc/articles/PMC8365127/ /pubmed/34399734 http://dx.doi.org/10.1186/s12935-021-02129-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Shafiee, Sepehr
Cegolon, Luca
Khafaei, Mostafa
Gholami, Nasrin
Zhao, Shi
Khalesi, Nasrin
Moosavian, Hamidreza
Fathi, Saeid
Izadi, Morteza
Ghadian, Alireza
Javanbakht, Mohammad
Javanbakht, Amin
Akhavan-Sigari, Reza
Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title_full Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title_fullStr Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title_full_unstemmed Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title_short Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19
title_sort gastrointestinal cancers, ace-2/tmprss2 expression and susceptibility to covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365127/
https://www.ncbi.nlm.nih.gov/pubmed/34399734
http://dx.doi.org/10.1186/s12935-021-02129-x
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