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Neural Conduction Along Postretinal Visual Pathways in Glaucoma

Purpose: This study was conducted in order to evaluate retinal ganglion cell (RCG) function and the neural conduction along the postretinal large and small axons and its correlation with retinal nerve fiber layer thickness (RNFL-T) in open-angle glaucoma (OAG) eyes. Methods: Thirty-seven OAG patient...

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Autores principales: Parisi, Vincenzo, Ziccardi, Lucia, Tanga, Lucia, Roberti, Gloria, Barbano, Lucilla, Carnevale, Carmela, Manni, Gianluca, Oddone, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365149/
https://www.ncbi.nlm.nih.gov/pubmed/34408643
http://dx.doi.org/10.3389/fnagi.2021.697425
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author Parisi, Vincenzo
Ziccardi, Lucia
Tanga, Lucia
Roberti, Gloria
Barbano, Lucilla
Carnevale, Carmela
Manni, Gianluca
Oddone, Francesco
author_facet Parisi, Vincenzo
Ziccardi, Lucia
Tanga, Lucia
Roberti, Gloria
Barbano, Lucilla
Carnevale, Carmela
Manni, Gianluca
Oddone, Francesco
author_sort Parisi, Vincenzo
collection PubMed
description Purpose: This study was conducted in order to evaluate retinal ganglion cell (RCG) function and the neural conduction along the postretinal large and small axons and its correlation with retinal nerve fiber layer thickness (RNFL-T) in open-angle glaucoma (OAG) eyes. Methods: Thirty-seven OAG patients (mean age: 51.68 ± 9.83 years) with 24–2 Humphrey mean deviation (MD) between −2.5 and −20 dB and IOP <21 mmHg on pharmacological treatment (OAG group) and 20 age-matched controls (control group) were enrolled. In both groups, simultaneous pattern electroretinograms (PERG) and visual evoked potentials (VEP), in response to checks stimulating macular or extramacular areas (the check edge subtended 15′ and 60′ of visual arc, respectively), and RNFL-T (measured in superior, inferior, nasal, and temporal quadrants) were assessed. Results: In the OAG group, a significant (ANOVA, p < 0.01) reduction of 60′ and 15′ PERG P50-N95 and VEP N75-P100 amplitudes and of RNFL-T [overall (average of all quadrants) or temporal] with respect to controls was found; the values of 60′ and 15′ PERG P50 and VEP P100 implicit times and of retinocortical time (RCT; difference between VEP P100 and PERG P50 implicit times) were significantly (p < 0.01) increased with respect to control ones. The observed increased RCTs were significantly linearly correlated (Pearson’s test, p < 0.01) with the reduced PERG amplitude and MD values, whereas no significant linear correlation (p < 0.01) with RNFL-T (overall or temporal) values was detected. Conclusions: In OAG, there is an impaired postretinal neural conduction along both large and small axons (increased 60′ and 15′ RCTs) that is related to RGC dysfunction, but independent from the RNFL morphology. This implies that, in OAG, the impairment of postretinal neural structures can be electrophysiologically identified and may contribute to the visual field defects, as suggested by the linear correlation between the increase of RCT and MD reduction.
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spelling pubmed-83651492021-08-17 Neural Conduction Along Postretinal Visual Pathways in Glaucoma Parisi, Vincenzo Ziccardi, Lucia Tanga, Lucia Roberti, Gloria Barbano, Lucilla Carnevale, Carmela Manni, Gianluca Oddone, Francesco Front Aging Neurosci Neuroscience Purpose: This study was conducted in order to evaluate retinal ganglion cell (RCG) function and the neural conduction along the postretinal large and small axons and its correlation with retinal nerve fiber layer thickness (RNFL-T) in open-angle glaucoma (OAG) eyes. Methods: Thirty-seven OAG patients (mean age: 51.68 ± 9.83 years) with 24–2 Humphrey mean deviation (MD) between −2.5 and −20 dB and IOP <21 mmHg on pharmacological treatment (OAG group) and 20 age-matched controls (control group) were enrolled. In both groups, simultaneous pattern electroretinograms (PERG) and visual evoked potentials (VEP), in response to checks stimulating macular or extramacular areas (the check edge subtended 15′ and 60′ of visual arc, respectively), and RNFL-T (measured in superior, inferior, nasal, and temporal quadrants) were assessed. Results: In the OAG group, a significant (ANOVA, p < 0.01) reduction of 60′ and 15′ PERG P50-N95 and VEP N75-P100 amplitudes and of RNFL-T [overall (average of all quadrants) or temporal] with respect to controls was found; the values of 60′ and 15′ PERG P50 and VEP P100 implicit times and of retinocortical time (RCT; difference between VEP P100 and PERG P50 implicit times) were significantly (p < 0.01) increased with respect to control ones. The observed increased RCTs were significantly linearly correlated (Pearson’s test, p < 0.01) with the reduced PERG amplitude and MD values, whereas no significant linear correlation (p < 0.01) with RNFL-T (overall or temporal) values was detected. Conclusions: In OAG, there is an impaired postretinal neural conduction along both large and small axons (increased 60′ and 15′ RCTs) that is related to RGC dysfunction, but independent from the RNFL morphology. This implies that, in OAG, the impairment of postretinal neural structures can be electrophysiologically identified and may contribute to the visual field defects, as suggested by the linear correlation between the increase of RCT and MD reduction. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8365149/ /pubmed/34408643 http://dx.doi.org/10.3389/fnagi.2021.697425 Text en Copyright © 2021 Parisi, Ziccardi, Tanga, Roberti, Barbano, Carnevale, Manni and Oddone. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Parisi, Vincenzo
Ziccardi, Lucia
Tanga, Lucia
Roberti, Gloria
Barbano, Lucilla
Carnevale, Carmela
Manni, Gianluca
Oddone, Francesco
Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title_full Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title_fullStr Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title_full_unstemmed Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title_short Neural Conduction Along Postretinal Visual Pathways in Glaucoma
title_sort neural conduction along postretinal visual pathways in glaucoma
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365149/
https://www.ncbi.nlm.nih.gov/pubmed/34408643
http://dx.doi.org/10.3389/fnagi.2021.697425
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