The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22

The SAGA coactivator complex is essential for eukaryotic transcription and comprises four distinct modules, one of which contains the ubiquitin hydrolase USP22. In yeast, the USP22 ortholog deubiquitylates H2B, resulting in Pol II Ser2 phosphorylation and subsequent transcriptional elongation. In co...

Descripción completa

Detalles Bibliográficos
Autores principales: Stanek, Timothy J, Gennaro, Victoria J, Tracewell, Mason A, Di Marcantonio, Daniela, Pauley, Kristen L, Butt, Sabrina, McNair, Christopher, Wang, Feng, Kossenkov, Andrew V, Knudsen, Karen E, Butt, Tauseef, Sykes, Stephen M, McMahon, Steven B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365265/
https://www.ncbi.nlm.nih.gov/pubmed/34155658
http://dx.doi.org/10.15252/embj.2019102509

Ejemplares similares

Ejemplares similares