The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity

The polypeptide drug thymalin is used for various diseases associated with immune dysfunction, viral and bacterial infections, regeneration normalization, immunodepression, and the depression of hematogenesis after chemical and radiotherapy. The molecular mechanism of the action of thymalin and its...

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Autores principales: Khavinson, V. Kh., Linkova, N. S., Chalisova, N. I., Ivko, O. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/
http://dx.doi.org/10.1134/S2079086421040046
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author Khavinson, V. Kh.
Linkova, N. S.
Chalisova, N. I.
Ivko, O. M.
author_facet Khavinson, V. Kh.
Linkova, N. S.
Chalisova, N. I.
Ivko, O. M.
author_sort Khavinson, V. Kh.
collection PubMed
description The polypeptide drug thymalin is used for various diseases associated with immune dysfunction, viral and bacterial infections, regeneration normalization, immunodepression, and the depression of hematogenesis after chemical and radiotherapy. The molecular mechanism of the action of thymalin and its components, EW dipeptide (the drug thymogen), the dipeptide KE, and the tripeptide EDP, are analyzed. These short peptides regulate gene expression and the synthesis of heat-shock protein, cytokines, fibrinolysis, gerontogenes, and the differentiation, proliferation, apoptosis of cells. Thymalin and thymogen have practically no side effects and are used for various viral infections. These peptide drugs can likely be effective in the complex therapy for the coronavirus infection COVID-19.
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spelling pubmed-83652932021-08-16 The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity Khavinson, V. Kh. Linkova, N. S. Chalisova, N. I. Ivko, O. M. Biol Bull Rev Article The polypeptide drug thymalin is used for various diseases associated with immune dysfunction, viral and bacterial infections, regeneration normalization, immunodepression, and the depression of hematogenesis after chemical and radiotherapy. The molecular mechanism of the action of thymalin and its components, EW dipeptide (the drug thymogen), the dipeptide KE, and the tripeptide EDP, are analyzed. These short peptides regulate gene expression and the synthesis of heat-shock protein, cytokines, fibrinolysis, gerontogenes, and the differentiation, proliferation, apoptosis of cells. Thymalin and thymogen have practically no side effects and are used for various viral infections. These peptide drugs can likely be effective in the complex therapy for the coronavirus infection COVID-19. Pleiades Publishing 2021-08-16 2021 /pmc/articles/PMC8365293/ http://dx.doi.org/10.1134/S2079086421040046 Text en © Pleiades Publishing, Ltd. 2021, ISSN 2079-0864, Biology Bulletin Reviews, 2021, Vol. 11, No. 4, pp. 377–382. © Pleiades Publishing, Ltd., 2021.Russian Text © The Author(s), 2021, published in Uspekhi Sovremennoi Biologii, 2021, Vol. 141, No. 1, pp. 25–31. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Khavinson, V. Kh.
Linkova, N. S.
Chalisova, N. I.
Ivko, O. M.
The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title_full The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title_fullStr The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title_full_unstemmed The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title_short The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity
title_sort use of thymalin for immunocorrection and molecular aspects of biological activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365293/
http://dx.doi.org/10.1134/S2079086421040046
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