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Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting

Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatm...

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Autores principales: Monzani, Dario, Petrocchi, Serena, Oliveri, Serena, Veldwijk, Jorien, Janssens, Rosanne, Bailo, Luca, Smith, Meredith Y., Smith, Ian, Schoefs, Elise, Nackaerts, Kristiaan, Vandevelde, Marie, Louis, Evelyne, Decaluwé, Herbert, De Leyn, Paul, Declerck, Hanne, Katz, Eva G., Petrella, Francesco, Casiraghi, Monica, Durosini, Ilaria, Galli, Giulia, Garassino, Marina Chiara, de Wit, G. Ardine, Pravettoni, Gabriella, Huys, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365300/
https://www.ncbi.nlm.nih.gov/pubmed/34409049
http://dx.doi.org/10.3389/fmed.2021.689114
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author Monzani, Dario
Petrocchi, Serena
Oliveri, Serena
Veldwijk, Jorien
Janssens, Rosanne
Bailo, Luca
Smith, Meredith Y.
Smith, Ian
Schoefs, Elise
Nackaerts, Kristiaan
Vandevelde, Marie
Louis, Evelyne
Decaluwé, Herbert
De Leyn, Paul
Declerck, Hanne
Katz, Eva G.
Petrella, Francesco
Casiraghi, Monica
Durosini, Ilaria
Galli, Giulia
Garassino, Marina Chiara
de Wit, G. Ardine
Pravettoni, Gabriella
Huys, Isabelle
author_facet Monzani, Dario
Petrocchi, Serena
Oliveri, Serena
Veldwijk, Jorien
Janssens, Rosanne
Bailo, Luca
Smith, Meredith Y.
Smith, Ian
Schoefs, Elise
Nackaerts, Kristiaan
Vandevelde, Marie
Louis, Evelyne
Decaluwé, Herbert
De Leyn, Paul
Declerck, Hanne
Katz, Eva G.
Petrella, Francesco
Casiraghi, Monica
Durosini, Ilaria
Galli, Giulia
Garassino, Marina Chiara
de Wit, G. Ardine
Pravettoni, Gabriella
Huys, Isabelle
author_sort Monzani, Dario
collection PubMed
description Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle.
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spelling pubmed-83653002021-08-17 Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting Monzani, Dario Petrocchi, Serena Oliveri, Serena Veldwijk, Jorien Janssens, Rosanne Bailo, Luca Smith, Meredith Y. Smith, Ian Schoefs, Elise Nackaerts, Kristiaan Vandevelde, Marie Louis, Evelyne Decaluwé, Herbert De Leyn, Paul Declerck, Hanne Katz, Eva G. Petrella, Francesco Casiraghi, Monica Durosini, Ilaria Galli, Giulia Garassino, Marina Chiara de Wit, G. Ardine Pravettoni, Gabriella Huys, Isabelle Front Med (Lausanne) Medicine Background: Advanced treatment options for non-small cell lung cancer (NSCLC) consist of immunotherapy, chemotherapy, or a combination of both. Decisions surrounding NSCLC can be considered as preference-sensitive because multiple treatments exist that vary in terms of mode of administration, treatment schedules, and benefit–risk profiles. As part of the IMI PREFER project, we developed a protocol for an online preference survey for NSCLC patients exploring differences in preferences according to patient characteristics (preference heterogeneity). Moreover, this study will evaluate and compare the use of two different preference elicitation methods, the discrete choice experiment (DCE) and the swing weighting (SW) task. Finally, the study explores how demographic (i.e., age, gender, and educational level) and clinical (i.e., cancer stage and line of treatment) information, health literacy, health locus of control, and quality of life may influence or explain patient preferences and the usefulness of a digital interactive tool in providing information on preference elicitation tasks according to patients. Methods: An online survey will be implemented with the aim to recruit 510 NSCLC patients in Belgium and Italy. Participants will be randomized 50:50 to first receive either the DCE or the SW. The survey will also collect information on participants' disease-related status, health locus of control, health literacy, quality of life, and perception of the educational tool. Discussion: This protocol outlines methodological and practical steps to quantitatively elicit and study patient preferences for NSCLC treatment alternatives. Results from this study will increase the understanding of which treatment aspects are most valued by NSCLC patients to inform decision-making in drug development, regulatory approval, and reimbursement. Methodologically, the comparison between the DCE and the SW task will be valuable to gain information on how these preference methods perform against each other in eliciting patient preferences. Overall, this protocol may assist researchers, drug developers, and decision-makers in designing quantitative patient preferences into decision-making along the medical product life cycle. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8365300/ /pubmed/34409049 http://dx.doi.org/10.3389/fmed.2021.689114 Text en Copyright © 2021 Monzani, Petrocchi, Oliveri, Veldwijk, Janssens, Bailo, Smith, Smith, Schoefs, Nackaerts, Vandevelde, Louis, Decaluwé, De Leyn, Declerck, Katz, Petrella, Casiraghi, Durosini, Galli, Garassino, de Wit, Pravettoni and Huys. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Monzani, Dario
Petrocchi, Serena
Oliveri, Serena
Veldwijk, Jorien
Janssens, Rosanne
Bailo, Luca
Smith, Meredith Y.
Smith, Ian
Schoefs, Elise
Nackaerts, Kristiaan
Vandevelde, Marie
Louis, Evelyne
Decaluwé, Herbert
De Leyn, Paul
Declerck, Hanne
Katz, Eva G.
Petrella, Francesco
Casiraghi, Monica
Durosini, Ilaria
Galli, Giulia
Garassino, Marina Chiara
de Wit, G. Ardine
Pravettoni, Gabriella
Huys, Isabelle
Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title_full Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title_fullStr Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title_full_unstemmed Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title_short Patient Preferences for Lung Cancer Treatments: A Study Protocol for a Preference Survey Using Discrete Choice Experiment and Swing Weighting
title_sort patient preferences for lung cancer treatments: a study protocol for a preference survey using discrete choice experiment and swing weighting
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365300/
https://www.ncbi.nlm.nih.gov/pubmed/34409049
http://dx.doi.org/10.3389/fmed.2021.689114
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