Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy

A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thro...

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Autores principales: Hara, Takuto, Terakawa, Tomoaki, Hyodo, Toshiki, Jinbo, Naoe, Nakano, Yuzo, Fujisawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365366/
https://www.ncbi.nlm.nih.gov/pubmed/34430210
http://dx.doi.org/10.1016/j.eucr.2021.101800
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author Hara, Takuto
Terakawa, Tomoaki
Hyodo, Toshiki
Jinbo, Naoe
Nakano, Yuzo
Fujisawa, Masato
author_facet Hara, Takuto
Terakawa, Tomoaki
Hyodo, Toshiki
Jinbo, Naoe
Nakano, Yuzo
Fujisawa, Masato
author_sort Hara, Takuto
collection PubMed
description A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4.
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spelling pubmed-83653662021-08-23 Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy Hara, Takuto Terakawa, Tomoaki Hyodo, Toshiki Jinbo, Naoe Nakano, Yuzo Fujisawa, Masato Urol Case Rep Oncology A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4. Elsevier 2021-08-09 /pmc/articles/PMC8365366/ /pubmed/34430210 http://dx.doi.org/10.1016/j.eucr.2021.101800 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Hara, Takuto
Terakawa, Tomoaki
Hyodo, Toshiki
Jinbo, Naoe
Nakano, Yuzo
Fujisawa, Masato
Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_full Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_fullStr Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_full_unstemmed Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_short Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_sort pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant tki/io combination therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365366/
https://www.ncbi.nlm.nih.gov/pubmed/34430210
http://dx.doi.org/10.1016/j.eucr.2021.101800
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