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Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults

Atypical eye movement patterns demonstrated by individuals with autism spectrum disorder (ASD) have the potential to serve as biomarkers for ASD diagnosis. However, instead of estimating individual differences in the degree of ASD from those patterns, many researchers have compared ASD groups with t...

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Detalles Bibliográficos
Autores principales: Kanari, Kei, Kikuchi-Ito, Moe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365375/
https://www.ncbi.nlm.nih.gov/pubmed/34430740
http://dx.doi.org/10.1016/j.heliyon.2021.e07751
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author Kanari, Kei
Kikuchi-Ito, Moe
author_facet Kanari, Kei
Kikuchi-Ito, Moe
author_sort Kanari, Kei
collection PubMed
description Atypical eye movement patterns demonstrated by individuals with autism spectrum disorder (ASD) have the potential to serve as biomarkers for ASD diagnosis. However, instead of estimating individual differences in the degree of ASD from those patterns, many researchers have compared ASD groups with typical development groups. This study investigates the relationship between the Autism-spectrum Quotient (AQ) scores in typical adults, which can evaluate the degree of the traits associated with ASD, as well as the properties of optokinetic nystagmus (OKN), including the gain of the slow phase, the peak velocity and duration of the fast phase, the frequency, and the mean eye position of OKN. A random dot pattern that moved in one direction was presented on the display, and the participants' eye movements were measured. The results showed a negative correlation between subjects' AQ scores and the gain of slow-phase OKN. In addition, the correlations between subjects' AQ scores and the properties of OKN fast phase were not significant. These results indicate that the gain of slow-phase OKN could be a biomarker that estimates individual differences in the degree of ASD, reflected in our findings which considered AQ scores in typical adults.
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spelling pubmed-83653752021-08-23 Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults Kanari, Kei Kikuchi-Ito, Moe Heliyon Research Article Atypical eye movement patterns demonstrated by individuals with autism spectrum disorder (ASD) have the potential to serve as biomarkers for ASD diagnosis. However, instead of estimating individual differences in the degree of ASD from those patterns, many researchers have compared ASD groups with typical development groups. This study investigates the relationship between the Autism-spectrum Quotient (AQ) scores in typical adults, which can evaluate the degree of the traits associated with ASD, as well as the properties of optokinetic nystagmus (OKN), including the gain of the slow phase, the peak velocity and duration of the fast phase, the frequency, and the mean eye position of OKN. A random dot pattern that moved in one direction was presented on the display, and the participants' eye movements were measured. The results showed a negative correlation between subjects' AQ scores and the gain of slow-phase OKN. In addition, the correlations between subjects' AQ scores and the properties of OKN fast phase were not significant. These results indicate that the gain of slow-phase OKN could be a biomarker that estimates individual differences in the degree of ASD, reflected in our findings which considered AQ scores in typical adults. Elsevier 2021-08-10 /pmc/articles/PMC8365375/ /pubmed/34430740 http://dx.doi.org/10.1016/j.heliyon.2021.e07751 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kanari, Kei
Kikuchi-Ito, Moe
Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title_full Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title_fullStr Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title_full_unstemmed Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title_short Estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
title_sort estimation of the degree of autism spectrum disorder by the slow phase of optokinetic nystagmus in typical adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365375/
https://www.ncbi.nlm.nih.gov/pubmed/34430740
http://dx.doi.org/10.1016/j.heliyon.2021.e07751
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