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Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors

Tubulin is a well-validated target for herbicides, fungicides, anti-parasitic, and anti-tumor drugs. Many of the non-cancer tubulin drugs bind to its colchicine site but no colchicine-site anticancer drug is available. The colchicine site is composed of three interconnected sub-pockets that fit thei...

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Detalles Bibliográficos
Autores principales:	Gallego-Yerga, Laura, Ochoa, Rodrigo, Lans, Isaías, Peña-Varas, Carlos, Alegría-Arcos, Melissa, Cossio, Pilar, Ramírez, David, Peláez, Rafael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365384/ https://www.ncbi.nlm.nih.gov/pubmed/34429853 http://dx.doi.org/10.1016/j.csbj.2021.07.039

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