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The LINC Between Mechanical Forces and Chromatin
The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper heart morphogenesis, postnatal growth, and fu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365421/ https://www.ncbi.nlm.nih.gov/pubmed/34408666 http://dx.doi.org/10.3389/fphys.2021.710809 |
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author | Lityagina, Olga Dobreva, Gergana |
author_facet | Lityagina, Olga Dobreva, Gergana |
author_sort | Lityagina, Olga |
collection | PubMed |
description | The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper heart morphogenesis, postnatal growth, and function. Defects in mechanotransduction, the ability of cells to convert mechanical stimuli into biochemical signals, are implicated in cardiovascular disease development and progression. In this review, we summarize the current knowledge on how mechanical forces are transduced to chromatin through the tensed actomyosin cytoskeleton, the linker of nucleoskeleton and cytoskeleton (LINC) complex and the nuclear lamina. We also discuss the functional significance of the LINC complex in cardiovascular disease. |
format | Online Article Text |
id | pubmed-8365421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83654212021-08-17 The LINC Between Mechanical Forces and Chromatin Lityagina, Olga Dobreva, Gergana Front Physiol Physiology The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper heart morphogenesis, postnatal growth, and function. Defects in mechanotransduction, the ability of cells to convert mechanical stimuli into biochemical signals, are implicated in cardiovascular disease development and progression. In this review, we summarize the current knowledge on how mechanical forces are transduced to chromatin through the tensed actomyosin cytoskeleton, the linker of nucleoskeleton and cytoskeleton (LINC) complex and the nuclear lamina. We also discuss the functional significance of the LINC complex in cardiovascular disease. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8365421/ /pubmed/34408666 http://dx.doi.org/10.3389/fphys.2021.710809 Text en Copyright © 2021 Lityagina and Dobreva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lityagina, Olga Dobreva, Gergana The LINC Between Mechanical Forces and Chromatin |
title | The LINC Between Mechanical Forces and Chromatin |
title_full | The LINC Between Mechanical Forces and Chromatin |
title_fullStr | The LINC Between Mechanical Forces and Chromatin |
title_full_unstemmed | The LINC Between Mechanical Forces and Chromatin |
title_short | The LINC Between Mechanical Forces and Chromatin |
title_sort | linc between mechanical forces and chromatin |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365421/ https://www.ncbi.nlm.nih.gov/pubmed/34408666 http://dx.doi.org/10.3389/fphys.2021.710809 |
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