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A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy

BACKGROUND: The preoperative diagnosis of pulmonary sclerosing pneumocytoma (PSP) is complicated since PSP has several histological structural patterns in the same neoplasm; hence, it is sometimes pathologically misdiagnosed as adenocarcinoma or carcinoid. In recent years, with the prevalence of tra...

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Autores principales: Muto, Yutaka, Kuse, Naoyuki, Inomata, Minoru, Awano, Nobuyasu, Tone, Mari, Minami, Jonsu, Takada, Kohei, Fujimoto, Kazushi, Wada, Ami, Nakao, Keita, Furuhata, Yoshiaki, Hori, Chisa, Bae, Yuan, Kumasaka, Toshio, Izumo, Takehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365508/
https://www.ncbi.nlm.nih.gov/pubmed/34430194
http://dx.doi.org/10.1016/j.rmcr.2021.101494
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author Muto, Yutaka
Kuse, Naoyuki
Inomata, Minoru
Awano, Nobuyasu
Tone, Mari
Minami, Jonsu
Takada, Kohei
Fujimoto, Kazushi
Wada, Ami
Nakao, Keita
Furuhata, Yoshiaki
Hori, Chisa
Bae, Yuan
Kumasaka, Toshio
Izumo, Takehiro
author_facet Muto, Yutaka
Kuse, Naoyuki
Inomata, Minoru
Awano, Nobuyasu
Tone, Mari
Minami, Jonsu
Takada, Kohei
Fujimoto, Kazushi
Wada, Ami
Nakao, Keita
Furuhata, Yoshiaki
Hori, Chisa
Bae, Yuan
Kumasaka, Toshio
Izumo, Takehiro
author_sort Muto, Yutaka
collection PubMed
description BACKGROUND: The preoperative diagnosis of pulmonary sclerosing pneumocytoma (PSP) is complicated since PSP has several histological structural patterns in the same neoplasm; hence, it is sometimes pathologically misdiagnosed as adenocarcinoma or carcinoid. In recent years, with the prevalence of transbronchial cryobiopsy (TBLC), we are able to obtain larger specimens than previously. However, to date, there have been no reports describing PSP diagnosed using TBLC. CASE REPORTS: A 43-year-old man was referred to our hospital for an abnormal lesion in the left lung discovered on routine health examination. A computed tomography scan of the chest revealed a 14-mm heterogeneous round nodule with surrounding ground-glass opacity in the left lower lobe. The tumor size increased to 18 mm in three weeks, and he developed bloody sputum. TBLC was performed using radial endobronchial ultrasonography and fluoroscopy. An occlusion balloon and prophylactic epinephrine were used to prevent severe bleeding. Histologically, epithelioid cells with solid proliferation, various papillary lesions, and hemosiderin-laden histiocytes were observed. Immunohistochemical staining revealed the histiocytes positive for thyroid transcription factor-1 and vimentin, and the type II pneumocyte-like-cells positive for cytokeratin 7. The tumor was preoperatively diagnosed as a PSP; the patient underwent left basal segmentectomy and consequently, a final diagnosed of PSP was formulated. CONCLUSION: We report the first case of PSP preoperatively diagnosed using TBLC. Therefore, cryobiopsy could be beneficial in the preoperative diagnosis of PSP.
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spelling pubmed-83655082021-08-23 A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy Muto, Yutaka Kuse, Naoyuki Inomata, Minoru Awano, Nobuyasu Tone, Mari Minami, Jonsu Takada, Kohei Fujimoto, Kazushi Wada, Ami Nakao, Keita Furuhata, Yoshiaki Hori, Chisa Bae, Yuan Kumasaka, Toshio Izumo, Takehiro Respir Med Case Rep Case Report BACKGROUND: The preoperative diagnosis of pulmonary sclerosing pneumocytoma (PSP) is complicated since PSP has several histological structural patterns in the same neoplasm; hence, it is sometimes pathologically misdiagnosed as adenocarcinoma or carcinoid. In recent years, with the prevalence of transbronchial cryobiopsy (TBLC), we are able to obtain larger specimens than previously. However, to date, there have been no reports describing PSP diagnosed using TBLC. CASE REPORTS: A 43-year-old man was referred to our hospital for an abnormal lesion in the left lung discovered on routine health examination. A computed tomography scan of the chest revealed a 14-mm heterogeneous round nodule with surrounding ground-glass opacity in the left lower lobe. The tumor size increased to 18 mm in three weeks, and he developed bloody sputum. TBLC was performed using radial endobronchial ultrasonography and fluoroscopy. An occlusion balloon and prophylactic epinephrine were used to prevent severe bleeding. Histologically, epithelioid cells with solid proliferation, various papillary lesions, and hemosiderin-laden histiocytes were observed. Immunohistochemical staining revealed the histiocytes positive for thyroid transcription factor-1 and vimentin, and the type II pneumocyte-like-cells positive for cytokeratin 7. The tumor was preoperatively diagnosed as a PSP; the patient underwent left basal segmentectomy and consequently, a final diagnosed of PSP was formulated. CONCLUSION: We report the first case of PSP preoperatively diagnosed using TBLC. Therefore, cryobiopsy could be beneficial in the preoperative diagnosis of PSP. Elsevier 2021-08-11 /pmc/articles/PMC8365508/ /pubmed/34430194 http://dx.doi.org/10.1016/j.rmcr.2021.101494 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Muto, Yutaka
Kuse, Naoyuki
Inomata, Minoru
Awano, Nobuyasu
Tone, Mari
Minami, Jonsu
Takada, Kohei
Fujimoto, Kazushi
Wada, Ami
Nakao, Keita
Furuhata, Yoshiaki
Hori, Chisa
Bae, Yuan
Kumasaka, Toshio
Izumo, Takehiro
A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title_full A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title_fullStr A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title_full_unstemmed A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title_short A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
title_sort case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365508/
https://www.ncbi.nlm.nih.gov/pubmed/34430194
http://dx.doi.org/10.1016/j.rmcr.2021.101494
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