Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

[Image: see text] Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichrom...

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Autores principales: Neukirch, Konstantin, Alsabil, Khaled, Dinh, Chau-Phi, Bilancia, Rossella, Raasch, Martin, Ville, Alexia, Cerqua, Ida, Viault, Guillaume, Bréard, Dimitri, Pace, Simona, Temml, Veronika, Brunner, Elena, Jordan, Paul M., Marques, Marta C., Loeser, Konstantin, Gollowitzer, André, Permann, Stephan, Gerstmeier, Jana, Lorkowski, Stefan, Stuppner, Hermann, Garscha, Ulrike, Rodrigues, Tiago, Bernardes, Gonçalo J. L., Schuster, Daniela, Séraphin, Denis, Richomme, Pascal, Rossi, Antonietta, Mosig, Alexander S., Roviezzo, Fiorentina, Werz, Oliver, Helesbeux, Jean-Jacques, Koeberle, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365602/
https://www.ncbi.nlm.nih.gov/pubmed/34279935
http://dx.doi.org/10.1021/acs.jmedchem.1c00806

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