Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

[Image: see text] CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for the develop...

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Detalles Bibliográficos
Autores principales: Eduful, Benjamin J., O’Byrne, Sean N., Temme, Louisa, Asquith, Christopher R. M., Liang, Yi, Picado, Alfredo, Pilotte, Joseph R., Hossain, Mohammad Anwar, Wells, Carrow I., Zuercher, William J., Catta-Preta, Carolina M. C., Zonzini Ramos, Priscila, Santiago, André de S., Couñago, Rafael M., Langendorf, Christopher G., Nay, Kévin, Oakhill, Jonathan S., Pulliam, Thomas L., Lin, Chenchu, Awad, Dominik, Willson, Timothy M., Frigo, Daniel E., Scott, John W., Drewry, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365604/
https://www.ncbi.nlm.nih.gov/pubmed/34264658
http://dx.doi.org/10.1021/acs.jmedchem.0c02274

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