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Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus

OBJECTIVE: As an integrated system, pancreatic microcirculatory disturbance plays a vital role in the pathogenesis of type 1 diabetes mellitus (T1DM), which involves changes in microcirculatory oxygen and microhemodynamics. Therefore, we aimed to release type 1 diabetic and insulin‐administrated mic...

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Autores principales: Li, Yuan, Li, Bingwei, Wang, Bing, Liu, Mingming, Zhang, Xiaoyan, Li, Ailing, Zhang, Jian, Zhang, Honggang, Xiu, Ruijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365673/
https://www.ncbi.nlm.nih.gov/pubmed/33655585
http://dx.doi.org/10.1111/micc.12691
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author Li, Yuan
Li, Bingwei
Wang, Bing
Liu, Mingming
Zhang, Xiaoyan
Li, Ailing
Zhang, Jian
Zhang, Honggang
Xiu, Ruijuan
author_facet Li, Yuan
Li, Bingwei
Wang, Bing
Liu, Mingming
Zhang, Xiaoyan
Li, Ailing
Zhang, Jian
Zhang, Honggang
Xiu, Ruijuan
author_sort Li, Yuan
collection PubMed
description OBJECTIVE: As an integrated system, pancreatic microcirculatory disturbance plays a vital role in the pathogenesis of type 1 diabetes mellitus (T1DM), which involves changes in microcirculatory oxygen and microhemodynamics. Therefore, we aimed to release type 1 diabetic and insulin‐administrated microcirculatory profiles of the pancreas. METHODS: BALB/c mice were assigned to control, T1DM, and insulin‐administrated groups randomly. T1DM was induced by intraperitoneal injection of streptozotocin (STZ). 1.5 IU insulin was administrated subcutaneously to keep the blood glucose within the normal range. After anesthetizing by isoflurane, the raw data set of pancreatic microcirculation was collected by the multimodal device– and computer algorithm–based microcirculatory evaluating system. After adjusting outliers and normalization, pancreatic microcirculatory oxygen and microhemodynamic data sets were imported into the three‐dimensional module and compared. RESULTS: Microcirculatory profiles of the pancreas in T1DM exhibited a loss of microhemodynamic coherence (significantly decreased microvascular blood perfusion) accompanied by an impaired oxygen balance (significantly decreased PO(2), SO(2), and rHb). More importantly, with insulin administration, the pathological microcirculatory profiles were partially restored. Meanwhile, there were correlations between pancreatic microcirculatory blood perfusion and PO(2) levels. CONCLUSIONS: Our findings establish the first integrated three‐dimensional pancreatic microcirculatory profiles of STZ‐induced and insulin‐administrated T1DM.
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spelling pubmed-83656732021-08-23 Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus Li, Yuan Li, Bingwei Wang, Bing Liu, Mingming Zhang, Xiaoyan Li, Ailing Zhang, Jian Zhang, Honggang Xiu, Ruijuan Microcirculation Original Articles OBJECTIVE: As an integrated system, pancreatic microcirculatory disturbance plays a vital role in the pathogenesis of type 1 diabetes mellitus (T1DM), which involves changes in microcirculatory oxygen and microhemodynamics. Therefore, we aimed to release type 1 diabetic and insulin‐administrated microcirculatory profiles of the pancreas. METHODS: BALB/c mice were assigned to control, T1DM, and insulin‐administrated groups randomly. T1DM was induced by intraperitoneal injection of streptozotocin (STZ). 1.5 IU insulin was administrated subcutaneously to keep the blood glucose within the normal range. After anesthetizing by isoflurane, the raw data set of pancreatic microcirculation was collected by the multimodal device– and computer algorithm–based microcirculatory evaluating system. After adjusting outliers and normalization, pancreatic microcirculatory oxygen and microhemodynamic data sets were imported into the three‐dimensional module and compared. RESULTS: Microcirculatory profiles of the pancreas in T1DM exhibited a loss of microhemodynamic coherence (significantly decreased microvascular blood perfusion) accompanied by an impaired oxygen balance (significantly decreased PO(2), SO(2), and rHb). More importantly, with insulin administration, the pathological microcirculatory profiles were partially restored. Meanwhile, there were correlations between pancreatic microcirculatory blood perfusion and PO(2) levels. CONCLUSIONS: Our findings establish the first integrated three‐dimensional pancreatic microcirculatory profiles of STZ‐induced and insulin‐administrated T1DM. John Wiley and Sons Inc. 2021-03-11 2021-07 /pmc/articles/PMC8365673/ /pubmed/33655585 http://dx.doi.org/10.1111/micc.12691 Text en © 2021 The Authors. Microcirculation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Li, Yuan
Li, Bingwei
Wang, Bing
Liu, Mingming
Zhang, Xiaoyan
Li, Ailing
Zhang, Jian
Zhang, Honggang
Xiu, Ruijuan
Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title_full Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title_fullStr Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title_full_unstemmed Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title_short Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
title_sort integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365673/
https://www.ncbi.nlm.nih.gov/pubmed/33655585
http://dx.doi.org/10.1111/micc.12691
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