Cargando…

Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System

Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane traffic, among many others, are strictly regulated to ensure functional success. S...

Descripción completa

Detalles Bibliográficos
Autores principales: Delgado-Román, Irene, Muñoz-Centeno, Mari Cruz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365833/
https://www.ncbi.nlm.nih.gov/pubmed/34409067
http://dx.doi.org/10.3389/fmolb.2021.691636
_version_ 1783738787431448576
author Delgado-Román, Irene
Muñoz-Centeno, Mari Cruz
author_facet Delgado-Román, Irene
Muñoz-Centeno, Mari Cruz
author_sort Delgado-Román, Irene
collection PubMed
description Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane traffic, among many others, are strictly regulated to ensure functional success. Such systems or vital processes do not work and adjusts independently of each other. It is required to ensure coordination among them which requires communication, or crosstalk, between their different elements through the establishment of complex regulatory networks. Distortion of this coordination affects, not only the specific processes involved, but also the whole cell fate. However, the connection between some systems and cell fate, is not yet very well understood and opens lots of interesting questions. In this review, we focus on the coordination between the function of the three nuclear RNA polymerases and cell cycle progression. Although we mainly focus on the model organism Saccharomyces cerevisiae, different aspects and similarities in higher eukaryotes are also addressed. We will first focus on how the different phases of the cell cycle affect the RNA polymerases activity and then how RNA polymerases status impacts on cell cycle. A good example of how RNA polymerases functions impact on cell cycle is the ribosome biogenesis process, which needs the coordinated and balanced production of mRNAs and rRNAs synthesized by the three eukaryotic RNA polymerases. Distortions of this balance generates ribosome biogenesis alterations that can impact cell cycle progression. We also pay attention to those cases where specific cell cycle defects generate in response to repressed synthesis of ribosomal proteins or RNA polymerases assembly defects.
format Online
Article
Text
id pubmed-8365833
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83658332021-08-17 Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System Delgado-Román, Irene Muñoz-Centeno, Mari Cruz Front Mol Biosci Molecular Biosciences Eukaryotic life is possible due to the multitude of complex and precise phenomena that take place in the cell. Essential processes like gene transcription, mRNA translation, cell growth, and proliferation, or membrane traffic, among many others, are strictly regulated to ensure functional success. Such systems or vital processes do not work and adjusts independently of each other. It is required to ensure coordination among them which requires communication, or crosstalk, between their different elements through the establishment of complex regulatory networks. Distortion of this coordination affects, not only the specific processes involved, but also the whole cell fate. However, the connection between some systems and cell fate, is not yet very well understood and opens lots of interesting questions. In this review, we focus on the coordination between the function of the three nuclear RNA polymerases and cell cycle progression. Although we mainly focus on the model organism Saccharomyces cerevisiae, different aspects and similarities in higher eukaryotes are also addressed. We will first focus on how the different phases of the cell cycle affect the RNA polymerases activity and then how RNA polymerases status impacts on cell cycle. A good example of how RNA polymerases functions impact on cell cycle is the ribosome biogenesis process, which needs the coordinated and balanced production of mRNAs and rRNAs synthesized by the three eukaryotic RNA polymerases. Distortions of this balance generates ribosome biogenesis alterations that can impact cell cycle progression. We also pay attention to those cases where specific cell cycle defects generate in response to repressed synthesis of ribosomal proteins or RNA polymerases assembly defects. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8365833/ /pubmed/34409067 http://dx.doi.org/10.3389/fmolb.2021.691636 Text en Copyright © 2021 Delgado-Román and Muñoz-Centeno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Delgado-Román, Irene
Muñoz-Centeno, Mari Cruz
Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title_full Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title_fullStr Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title_full_unstemmed Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title_short Coupling Between Cell Cycle Progression and the Nuclear RNA Polymerases System
title_sort coupling between cell cycle progression and the nuclear rna polymerases system
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365833/
https://www.ncbi.nlm.nih.gov/pubmed/34409067
http://dx.doi.org/10.3389/fmolb.2021.691636
work_keys_str_mv AT delgadoromanirene couplingbetweencellcycleprogressionandthenuclearrnapolymerasessystem
AT munozcentenomaricruz couplingbetweencellcycleprogressionandthenuclearrnapolymerasessystem