Cargando…

Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study

In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Clima...

Descripción completa

Detalles Bibliográficos
Autores principales: Corozolla, W., Zago, V.H.S., Marson, F.A.L., de Avila, A.M.H., Costa, P.D.P., Teixeira, L.S., Dalpino, F., de Faria, E.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365875/
https://www.ncbi.nlm.nih.gov/pubmed/34378675
http://dx.doi.org/10.1590/1414-431X2021e11035
_version_ 1783738798349221888
author Corozolla, W.
Zago, V.H.S.
Marson, F.A.L.
de Avila, A.M.H.
Costa, P.D.P.
Teixeira, L.S.
Dalpino, F.
de Faria, E.C.
author_facet Corozolla, W.
Zago, V.H.S.
Marson, F.A.L.
de Avila, A.M.H.
Costa, P.D.P.
Teixeira, L.S.
Dalpino, F.
de Faria, E.C.
author_sort Corozolla, W.
collection PubMed
description In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime.
format Online
Article
Text
id pubmed-8365875
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Associação Brasileira de Divulgação Científica
record_format MEDLINE/PubMed
spelling pubmed-83658752021-08-26 Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study Corozolla, W. Zago, V.H.S. Marson, F.A.L. de Avila, A.M.H. Costa, P.D.P. Teixeira, L.S. Dalpino, F. de Faria, E.C. Braz J Med Biol Res Research Article In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime. Associação Brasileira de Divulgação Científica 2021-08-06 /pmc/articles/PMC8365875/ /pubmed/34378675 http://dx.doi.org/10.1590/1414-431X2021e11035 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Corozolla, W.
Zago, V.H.S.
Marson, F.A.L.
de Avila, A.M.H.
Costa, P.D.P.
Teixeira, L.S.
Dalpino, F.
de Faria, E.C.
Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title_full Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title_fullStr Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title_full_unstemmed Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title_short Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
title_sort associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large brazilian population of campinas, são paulo state: an eight-year study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365875/
https://www.ncbi.nlm.nih.gov/pubmed/34378675
http://dx.doi.org/10.1590/1414-431X2021e11035
work_keys_str_mv AT corozollaw associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT zagovhs associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT marsonfal associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT deavilaamh associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT costapdp associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT teixeirals associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT dalpinof associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy
AT defariaec associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy