Cargando…
Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study
In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Clima...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365875/ https://www.ncbi.nlm.nih.gov/pubmed/34378675 http://dx.doi.org/10.1590/1414-431X2021e11035 |
_version_ | 1783738798349221888 |
---|---|
author | Corozolla, W. Zago, V.H.S. Marson, F.A.L. de Avila, A.M.H. Costa, P.D.P. Teixeira, L.S. Dalpino, F. de Faria, E.C. |
author_facet | Corozolla, W. Zago, V.H.S. Marson, F.A.L. de Avila, A.M.H. Costa, P.D.P. Teixeira, L.S. Dalpino, F. de Faria, E.C. |
author_sort | Corozolla, W. |
collection | PubMed |
description | In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime. |
format | Online Article Text |
id | pubmed-8365875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Associação Brasileira de Divulgação Científica |
record_format | MEDLINE/PubMed |
spelling | pubmed-83658752021-08-26 Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study Corozolla, W. Zago, V.H.S. Marson, F.A.L. de Avila, A.M.H. Costa, P.D.P. Teixeira, L.S. Dalpino, F. de Faria, E.C. Braz J Med Biol Res Research Article In this eight-year retrospective study, we evaluated the associations between climatic variations and the biological rhythms in plasma lipids and lipoproteins in a large population of Campinas, São Paulo state, Brazil, as well as temporal changes of outcomes of cardiovascular hospitalizations. Climatic variables were obtained at the Center for Meteorological and Climatic Research Applied to Agriculture (University of Campinas - Unicamp, Brazil). The plasma lipid databases surveyed were from 27,543 individuals who had their lipid profiles assessed at the state university referral hospital in Campinas (Unicamp). The frequency of hospitalizations was obtained from the Brazilian Public Health database (DATASUS). Temporal statistical analyses were performed using the methods Cosinor or Friedman (ARIMA) and the temporal series were compared by cross-correlation functions. In normolipidemic cases (n=11,892), significantly different rhythmicity was observed in low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol (C) both higher in winter and lower in summer. Dyslipidemia (n=15,651) increased the number and amplitude of lipid rhythms: LDL-C and HDL-C were higher in winter and lower in summer, and the opposite occurred with triglycerides. The number of hospitalizations showed maximum and minimum frequencies in winter and in summer, respectively. A coincident rhythmicity was observed of lower temperature and humidity rates with higher plasma LDL-C, and their temporal series were inversely cross-correlated. This study shows for the first time that variations of temperature, humidity, and daylight length were strongly associated with LDL-C and HDL-C seasonality, but moderately to lowly associated with rhythmicity of atherosclerotic outcomes. It also indicates unfavorable cardiovascular-related changes during wintertime. Associação Brasileira de Divulgação Científica 2021-08-06 /pmc/articles/PMC8365875/ /pubmed/34378675 http://dx.doi.org/10.1590/1414-431X2021e11035 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Corozolla, W. Zago, V.H.S. Marson, F.A.L. de Avila, A.M.H. Costa, P.D.P. Teixeira, L.S. Dalpino, F. de Faria, E.C. Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title_full | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title_fullStr | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title_full_unstemmed | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title_short | Associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large Brazilian population of Campinas, São Paulo state: an eight-year study |
title_sort | associations of plasma lipids, lipoproteins, and cardiovascular outcomes with climatic variations in a large brazilian population of campinas, são paulo state: an eight-year study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365875/ https://www.ncbi.nlm.nih.gov/pubmed/34378675 http://dx.doi.org/10.1590/1414-431X2021e11035 |
work_keys_str_mv | AT corozollaw associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT zagovhs associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT marsonfal associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT deavilaamh associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT costapdp associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT teixeirals associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT dalpinof associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy AT defariaec associationsofplasmalipidslipoproteinsandcardiovascularoutcomeswithclimaticvariationsinalargebrazilianpopulationofcampinassaopaulostateaneightyearstudy |