Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

BACKGROUND: Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was reported...

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Detalles Bibliográficos
Autores principales: Wu, Fan, Shao, Qingqing, Cheng, Zhe, Xiong, Xinyu, Fang, Ke, Zhao, Yan, Dong, Ruolan, Xu, Lijun, Lu, Fuer, Chen, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365910/
https://www.ncbi.nlm.nih.gov/pubmed/34399822
http://dx.doi.org/10.1186/s13020-021-00493-4

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