Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates

Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence of attention deficit hyperactivity disorder is elevated in children with DS. The aneuploid DS mouse model “Ts65Dn” shows prominent brain phenotypes, in...

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Detalles Bibliográficos
Autores principales: Gao, Feng J., Klinedinst, Donna, Fernandez, Fabian-Xosé, Cheng, Bei, Savonenko, Alena, Devenney, Benjamin, Li, Yicong, Wu, Dan, Pomper, Martin G., Reeves, Roger H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365939/
https://www.ncbi.nlm.nih.gov/pubmed/34399854
http://dx.doi.org/10.1186/s40478-021-01237-z

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