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Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension
BACKGROUND: Left‐sided portal hypertension is usually found in patients undergoing pancreaticoduodenectomy (PD) with spleno‐mesenterico‐portal (S‐M‐P) confluence resection. This study is to explore the outcomes of S‐M‐P confluence reconstruction after resection by using bifurcated allogeneic vein. M...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366088/ https://www.ncbi.nlm.nih.gov/pubmed/34190423 http://dx.doi.org/10.1002/cam4.4093 |
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author | Zhang, Xingmao Wu, Qiao Fan, Hua He, Qiang Lang, Ren |
author_facet | Zhang, Xingmao Wu, Qiao Fan, Hua He, Qiang Lang, Ren |
author_sort | Zhang, Xingmao |
collection | PubMed |
description | BACKGROUND: Left‐sided portal hypertension is usually found in patients undergoing pancreaticoduodenectomy (PD) with spleno‐mesenterico‐portal (S‐M‐P) confluence resection. This study is to explore the outcomes of S‐M‐P confluence reconstruction after resection by using bifurcated allogeneic vein. METHODS: Clinicopathologic data of patients who underwent extensive PD with S‐M‐P confluence resection for carcinoma of pancreatic head/uncinate process in our hospital between December 2011 and August 2018 were retrospectively reviewed and clinical outcomes of vein reconstruction after resection were analyzed. RESULTS: Of the 37 patients enrolled, S‐M‐P reconstruction by bifurcated allogeneic vein was performed in 24 cases (group 1) and simply splenic vein ligation in 13 cases (group 2). Items including pathological results, blood loss, and complications were comparable between the two groups, operation time was longer in group 1 (573.8 vs. 479.2 min, p = 0.018). Significantly decreased platelet count (205.9 vs. 133.1 × 10(9)/L, p = 0.001) and increased splenic volume (270.9 vs. 452.2 ml, p < 0.001) were observed in group 2 at 6 months after operation. The mean splenic hypertrophy ratio was 1.06 in group 1 and 1.63 in group 2, respectively (p < 0.001). There were four patients with varices were found in group 2, none in group 1. CONCLUSIONS: Without increased complications, reconstructing S‐M‐P confluence by bifurcated allogeneic vein after resection may help to avoid left‐sided portal hypertension. |
format | Online Article Text |
id | pubmed-8366088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83660882021-08-23 Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension Zhang, Xingmao Wu, Qiao Fan, Hua He, Qiang Lang, Ren Cancer Med Clinical Cancer Research BACKGROUND: Left‐sided portal hypertension is usually found in patients undergoing pancreaticoduodenectomy (PD) with spleno‐mesenterico‐portal (S‐M‐P) confluence resection. This study is to explore the outcomes of S‐M‐P confluence reconstruction after resection by using bifurcated allogeneic vein. METHODS: Clinicopathologic data of patients who underwent extensive PD with S‐M‐P confluence resection for carcinoma of pancreatic head/uncinate process in our hospital between December 2011 and August 2018 were retrospectively reviewed and clinical outcomes of vein reconstruction after resection were analyzed. RESULTS: Of the 37 patients enrolled, S‐M‐P reconstruction by bifurcated allogeneic vein was performed in 24 cases (group 1) and simply splenic vein ligation in 13 cases (group 2). Items including pathological results, blood loss, and complications were comparable between the two groups, operation time was longer in group 1 (573.8 vs. 479.2 min, p = 0.018). Significantly decreased platelet count (205.9 vs. 133.1 × 10(9)/L, p = 0.001) and increased splenic volume (270.9 vs. 452.2 ml, p < 0.001) were observed in group 2 at 6 months after operation. The mean splenic hypertrophy ratio was 1.06 in group 1 and 1.63 in group 2, respectively (p < 0.001). There were four patients with varices were found in group 2, none in group 1. CONCLUSIONS: Without increased complications, reconstructing S‐M‐P confluence by bifurcated allogeneic vein after resection may help to avoid left‐sided portal hypertension. John Wiley and Sons Inc. 2021-06-30 /pmc/articles/PMC8366088/ /pubmed/34190423 http://dx.doi.org/10.1002/cam4.4093 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Zhang, Xingmao Wu, Qiao Fan, Hua He, Qiang Lang, Ren Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title | Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title_full | Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title_fullStr | Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title_full_unstemmed | Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title_short | Reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
title_sort | reconstructing spleno‐mesenterico‐portal cofluence by bifurcated allogeneic vein in local advanced pancreatic cancer—a feasible method to avoid left‐sided portal hypertension |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366088/ https://www.ncbi.nlm.nih.gov/pubmed/34190423 http://dx.doi.org/10.1002/cam4.4093 |
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