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SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States
Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink–derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529)...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366104/ https://www.ncbi.nlm.nih.gov/pubmed/34109885 http://dx.doi.org/10.1177/10406387211023481 |
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author | Cai, Hugh Y. Cai, Allison |
author_facet | Cai, Hugh Y. Cai, Allison |
author_sort | Cai, Hugh Y. |
collection | PubMed |
description | Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink–derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink–derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States. |
format | Online Article Text |
id | pubmed-8366104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-83661042021-08-17 SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States Cai, Hugh Y. Cai, Allison J Vet Diagn Invest Brief Reports Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink–derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink–derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States. SAGE Publications 2021-06-10 2021-09 /pmc/articles/PMC8366104/ /pubmed/34109885 http://dx.doi.org/10.1177/10406387211023481 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Brief Reports Cai, Hugh Y. Cai, Allison SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title | SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title_full | SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title_fullStr | SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title_full_unstemmed | SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title_short | SARS-CoV2 spike protein gene variants with N501T and G142D mutation–dominated infections in mink in the United States |
title_sort | sars-cov2 spike protein gene variants with n501t and g142d mutation–dominated infections in mink in the united states |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366104/ https://www.ncbi.nlm.nih.gov/pubmed/34109885 http://dx.doi.org/10.1177/10406387211023481 |
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