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Design and numerical simulation for the development of an expandable paediatric heart valve

Current paediatric valve replacement options cannot compensate for somatic growth, leading to an obstruction of flow as the child outgrows the prosthesis. This often necessitates an increase in revision surgeries, leading to legacy issues into adulthood. An expandable valve concept was modelled with...

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Detalles Bibliográficos
Autores principales: Kerr, Monica M, Gourlay, Terence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366171/
https://www.ncbi.nlm.nih.gov/pubmed/33300423
http://dx.doi.org/10.1177/0391398820977509
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author Kerr, Monica M
Gourlay, Terence
author_facet Kerr, Monica M
Gourlay, Terence
author_sort Kerr, Monica M
collection PubMed
description Current paediatric valve replacement options cannot compensate for somatic growth, leading to an obstruction of flow as the child outgrows the prosthesis. This often necessitates an increase in revision surgeries, leading to legacy issues into adulthood. An expandable valve concept was modelled with an inverse relationship between annulus size and height, to retain the leaflet geometry without requiring additional intervention. Parametric design modelling was used to define certain valve parameter aspect ratios in relation to the base radius, R(b), including commissural radius, R(c), valve height, H and coaptation height, x. Fluid-structure simulations were subsequently carried out using the Immersed Boundary method to radially compress down the fully expanded aortic valve whilst subjecting it to diastolic and systolic loading cycles. Leaflet radial displacements were analysed to determine if valve performance is likely to be compromised following compression. Work is ongoing to optimise valvular parameter design for the paediatric patient cohort.
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spelling pubmed-83661712021-08-17 Design and numerical simulation for the development of an expandable paediatric heart valve Kerr, Monica M Gourlay, Terence Int J Artif Organs Original Research Articles Current paediatric valve replacement options cannot compensate for somatic growth, leading to an obstruction of flow as the child outgrows the prosthesis. This often necessitates an increase in revision surgeries, leading to legacy issues into adulthood. An expandable valve concept was modelled with an inverse relationship between annulus size and height, to retain the leaflet geometry without requiring additional intervention. Parametric design modelling was used to define certain valve parameter aspect ratios in relation to the base radius, R(b), including commissural radius, R(c), valve height, H and coaptation height, x. Fluid-structure simulations were subsequently carried out using the Immersed Boundary method to radially compress down the fully expanded aortic valve whilst subjecting it to diastolic and systolic loading cycles. Leaflet radial displacements were analysed to determine if valve performance is likely to be compromised following compression. Work is ongoing to optimise valvular parameter design for the paediatric patient cohort. SAGE Publications 2020-12-10 2021-07 /pmc/articles/PMC8366171/ /pubmed/33300423 http://dx.doi.org/10.1177/0391398820977509 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Articles
Kerr, Monica M
Gourlay, Terence
Design and numerical simulation for the development of an expandable paediatric heart valve
title Design and numerical simulation for the development of an expandable paediatric heart valve
title_full Design and numerical simulation for the development of an expandable paediatric heart valve
title_fullStr Design and numerical simulation for the development of an expandable paediatric heart valve
title_full_unstemmed Design and numerical simulation for the development of an expandable paediatric heart valve
title_short Design and numerical simulation for the development of an expandable paediatric heart valve
title_sort design and numerical simulation for the development of an expandable paediatric heart valve
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366171/
https://www.ncbi.nlm.nih.gov/pubmed/33300423
http://dx.doi.org/10.1177/0391398820977509
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