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Long Noncoding RNAs as Emerging Regulators of COVID-19
Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366413/ https://www.ncbi.nlm.nih.gov/pubmed/34408749 http://dx.doi.org/10.3389/fimmu.2021.700184 |
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author | Yang, Qinzhi Lin, Fang Wang, Yanan Zeng, Min Luo, Mao |
author_facet | Yang, Qinzhi Lin, Fang Wang, Yanan Zeng, Min Luo, Mao |
author_sort | Yang, Qinzhi |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radecivir, baritinib), monoclonal antibodies (tocilizumab), and glucocorticoids (dexamethasone). Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are essential regulators of virus infections and antiviral immune responses including biological processes that are involved in the regulation of COVID-19 and subsequent disease states. Upon viral infections, cellular lncRNAs directly regulate viral genes and influence viral replication and pathology through virus-mediated changes in the host transcriptome. Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. Consequently, understanding the expression and function of lncRNAs during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection will provide insights into the development of lncRNA-based methods. In this review, we summarized the current findings of lncRNAs in the regulation of the strong inflammatory response, immune dysfunction and thrombosis induced by SARS-CoV-2 infection, discussed the underlying mechanisms, and highlighted the therapeutic challenges of COVID-19 treatment and its future research directions. |
format | Online Article Text |
id | pubmed-8366413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83664132021-08-17 Long Noncoding RNAs as Emerging Regulators of COVID-19 Yang, Qinzhi Lin, Fang Wang, Yanan Zeng, Min Luo, Mao Front Immunol Immunology Coronavirus disease 2019 (COVID-19), which has high incidence rates with rapid rate of transmission, is a pandemic that spread across the world, resulting in more than 3,000,000 deaths globally. Currently, several drugs have been used for the clinical treatment of COVID-19, such as antivirals (radecivir, baritinib), monoclonal antibodies (tocilizumab), and glucocorticoids (dexamethasone). Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are essential regulators of virus infections and antiviral immune responses including biological processes that are involved in the regulation of COVID-19 and subsequent disease states. Upon viral infections, cellular lncRNAs directly regulate viral genes and influence viral replication and pathology through virus-mediated changes in the host transcriptome. Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. Consequently, understanding the expression and function of lncRNAs during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection will provide insights into the development of lncRNA-based methods. In this review, we summarized the current findings of lncRNAs in the regulation of the strong inflammatory response, immune dysfunction and thrombosis induced by SARS-CoV-2 infection, discussed the underlying mechanisms, and highlighted the therapeutic challenges of COVID-19 treatment and its future research directions. Frontiers Media S.A. 2021-08-02 /pmc/articles/PMC8366413/ /pubmed/34408749 http://dx.doi.org/10.3389/fimmu.2021.700184 Text en Copyright © 2021 Yang, Lin, Wang, Zeng and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Yang, Qinzhi Lin, Fang Wang, Yanan Zeng, Min Luo, Mao Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title | Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title_full | Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title_fullStr | Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title_full_unstemmed | Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title_short | Long Noncoding RNAs as Emerging Regulators of COVID-19 |
title_sort | long noncoding rnas as emerging regulators of covid-19 |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366413/ https://www.ncbi.nlm.nih.gov/pubmed/34408749 http://dx.doi.org/10.3389/fimmu.2021.700184 |
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