A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening

A novel capillary-based microfluidic strategy to accelerate the process of small-molecule-compound screening by room-temperature X-ray crystallography using protein crystals is reported. The ultra-thin microfluidic devices are composed of a UV-curable polymer, patterned by cleanroom photolithography...

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Detalles Bibliográficos
Autores principales: Sui, Shuo, Mulichak, Anne, Kulathila, Raviraj, McGee, Joshua, Filiatreault, Danny, Saha, Sarthak, Cohen, Aina, Song, Jinhu, Hung, Holly, Selway, Jonathan, Kirby, Christina, Shrestha, Om K., Weihofen, Wilhelm, Fodor, Michelle, Xu, Mei, Chopra, Rajiv, Perry, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366422/
https://www.ncbi.nlm.nih.gov/pubmed/34429718
http://dx.doi.org/10.1107/S1600576721004155

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