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Interpretation of vaccine associated neurological adverse events: a methodological and historical review

As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis...

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Autores principales: Cauchi, Marija, Ball, Harriet, Ben-Shlomo, Yoav, Robertson, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366487/
https://www.ncbi.nlm.nih.gov/pubmed/34398270
http://dx.doi.org/10.1007/s00415-021-10747-8
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author Cauchi, Marija
Ball, Harriet
Ben-Shlomo, Yoav
Robertson, Neil
author_facet Cauchi, Marija
Ball, Harriet
Ben-Shlomo, Yoav
Robertson, Neil
author_sort Cauchi, Marija
collection PubMed
description As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis and thrombocytopenia (VITT), have come to light which have the potential to undermine the success of the vaccination program. However, it can be difficult to interpret available data and put these into context and to communicate this effectively. In this review, we discuss contemporary methodologies employed to investigate possible associations between vaccination and adverse neurological outcomes and why determining causality can be challenging. We demonstrate these issues by discussing relevant historical exemplars and explore the relevance for the current pandemic and vaccination program. We also discuss challenges in understanding and communicating such risks to clinicians and the general population within the context of the ‘infodemic’ facilitated by the Internet and other media.
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spelling pubmed-83664872021-08-17 Interpretation of vaccine associated neurological adverse events: a methodological and historical review Cauchi, Marija Ball, Harriet Ben-Shlomo, Yoav Robertson, Neil J Neurol Neurological Update As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis and thrombocytopenia (VITT), have come to light which have the potential to undermine the success of the vaccination program. However, it can be difficult to interpret available data and put these into context and to communicate this effectively. In this review, we discuss contemporary methodologies employed to investigate possible associations between vaccination and adverse neurological outcomes and why determining causality can be challenging. We demonstrate these issues by discussing relevant historical exemplars and explore the relevance for the current pandemic and vaccination program. We also discuss challenges in understanding and communicating such risks to clinicians and the general population within the context of the ‘infodemic’ facilitated by the Internet and other media. Springer Berlin Heidelberg 2021-08-16 2022 /pmc/articles/PMC8366487/ /pubmed/34398270 http://dx.doi.org/10.1007/s00415-021-10747-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Neurological Update
Cauchi, Marija
Ball, Harriet
Ben-Shlomo, Yoav
Robertson, Neil
Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title_full Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title_fullStr Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title_full_unstemmed Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title_short Interpretation of vaccine associated neurological adverse events: a methodological and historical review
title_sort interpretation of vaccine associated neurological adverse events: a methodological and historical review
topic Neurological Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366487/
https://www.ncbi.nlm.nih.gov/pubmed/34398270
http://dx.doi.org/10.1007/s00415-021-10747-8
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