SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes and macrophages are sentinel immune cells...

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Detalles Bibliográficos
Autores principales: Junqueira, Caroline, Crespo, Ângela, Ranjbar, Shahin, Lewandrowski, Mercedes, Ingber, Jacob, de Lacerda, Luna B., Parry, Blair, Ravid, Sagi, Clark, Sarah, Ho, Felicia, Vora, Setu M., Leger, Valerie, Beakes, Caroline, Margolin, Justin, Russell, Nicole, Kays, Kyle, Gehrke, Lee, Adhikari, Upasana Das, Henderson, Lauren, Janssen, Erin, Kwon, Douglas, Sander, Chris, Abraham, Jonathan, Filbin, Michael, Goldberg, Marcia B., Wu, Hao, Mehta, Gautam, Bell, Steven, Goldfeld, Anne E., Lieberman, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366805/
https://www.ncbi.nlm.nih.gov/pubmed/34401873
http://dx.doi.org/10.21203/rs.3.rs-153628/v1

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