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A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects
Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major pla...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366996/ https://www.ncbi.nlm.nih.gov/pubmed/34347783 http://dx.doi.org/10.1371/journal.pbio.3001360 |
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author | Zhang, Xing Meng, Yamin Huang, Yizhou Zhang, Dan Fang, Weiguo |
author_facet | Zhang, Xing Meng, Yamin Huang, Yizhou Zhang, Dan Fang, Weiguo |
author_sort | Zhang, Xing |
collection | PubMed |
description | Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major plant and mammalian pathogenic fungi in its pathogenesis. Here we report on a novel cascade that regulates response of M. robertsii to 2 distinct microenvironments during its pathogenesis. On the insect cuticle, the transcription factor COH2 activates expression of cuticle penetration genes. In the hemocoel, the protein COH1 is expressed due to the reduction in epigenetic repression conferred by the histone deacetylase HDAC1 and the histone 3 acetyltransferase HAT1. COH1 interacts with COH2 to reduce COH2 stability, and this down-regulates cuticle penetration genes and up-regulates genes for hemocoel colonization. Our work significantly advances the insights into fungal pathogenicity in insects. |
format | Online Article Text |
id | pubmed-8366996 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83669962021-08-17 A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects Zhang, Xing Meng, Yamin Huang, Yizhou Zhang, Dan Fang, Weiguo PLoS Biol Research Article Pathogenic fungi precisely respond to dynamic microenvironments during infection, but the underlying mechanisms are not well understood. The insect pathogenic fungus Metarhizium robertsii is a representative fungus in which to study broad themes of fungal pathogenicity as it resembles some major plant and mammalian pathogenic fungi in its pathogenesis. Here we report on a novel cascade that regulates response of M. robertsii to 2 distinct microenvironments during its pathogenesis. On the insect cuticle, the transcription factor COH2 activates expression of cuticle penetration genes. In the hemocoel, the protein COH1 is expressed due to the reduction in epigenetic repression conferred by the histone deacetylase HDAC1 and the histone 3 acetyltransferase HAT1. COH1 interacts with COH2 to reduce COH2 stability, and this down-regulates cuticle penetration genes and up-regulates genes for hemocoel colonization. Our work significantly advances the insights into fungal pathogenicity in insects. Public Library of Science 2021-08-04 /pmc/articles/PMC8366996/ /pubmed/34347783 http://dx.doi.org/10.1371/journal.pbio.3001360 Text en © 2021 Zhang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhang, Xing Meng, Yamin Huang, Yizhou Zhang, Dan Fang, Weiguo A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title | A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title_full | A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title_fullStr | A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title_full_unstemmed | A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title_short | A novel cascade allows Metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
title_sort | novel cascade allows metarhizium robertsii to distinguish cuticle and hemocoel microenvironments during infection of insects |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366996/ https://www.ncbi.nlm.nih.gov/pubmed/34347783 http://dx.doi.org/10.1371/journal.pbio.3001360 |
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