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Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area

Toxicological evidence has shown that fine particulate matter (PM(2.5)) may affect distant organs, including kidneys, over the short term. However, epidemiological evidence is limited. OBJECTIVES: We investigated associations between short-term exposure to PM(2.5), major PM(2.5) components [elementa...

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Autores principales: Bi, Jianzhao, Barry, Vaughn, Weil, Ethel J., Chang, Howard H., Ebelt, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367053/
https://www.ncbi.nlm.nih.gov/pubmed/34414347
http://dx.doi.org/10.1097/EE9.0000000000000164
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author Bi, Jianzhao
Barry, Vaughn
Weil, Ethel J.
Chang, Howard H.
Ebelt, Stefanie
author_facet Bi, Jianzhao
Barry, Vaughn
Weil, Ethel J.
Chang, Howard H.
Ebelt, Stefanie
author_sort Bi, Jianzhao
collection PubMed
description Toxicological evidence has shown that fine particulate matter (PM(2.5)) may affect distant organs, including kidneys, over the short term. However, epidemiological evidence is limited. OBJECTIVES: We investigated associations between short-term exposure to PM(2.5), major PM(2.5) components [elemental carbon (EC), organic carbon (OC), sulfate, and nitrate], and gaseous co-pollutants (O(3), CO, SO(2), NO(2), and NO(x)) and emergency department (ED) visits for kidney diseases during 2002–2008 in Atlanta, Georgia. METHODS: Log-linear time-series models were fitted to estimate the acute effects of air pollution, with single-day and unconstrained distributed lags, on rates of ED visits for kidney diseases [all renal diseases and acute renal failure (ARF)], controlling for meteorology (maximum air and dew-point temperatures) and time (season, day of week, holidays, and long-term time trend). RESULTS: For all renal diseases, we observed positive associations for most air pollutants, particularly 8-day cumulative exposure to OC [rate ratio (RR) = 1.018, (95% confidence interval [CI]: 1.003, 1.034)] and EC [1.016 (1.000, 1.031)] per interquartile range increase exposure. For ARF, we observed positive associations particularly for 8-day exposure to OC [1.034 (1.005, 1.064)], EC [1.032 (1.002, 1.063)], nitrate [1.032 (0.996, 1.069)], and PM(2.5) [1.026 (0.997, 1.057)] per interquartile range increase exposure. We also observed positive associations for most criteria gases. The RR estimates were generally higher for ARF than all renal diseases. CONCLUSIONS: We observed positive associations between short-term exposure to fine particulate air pollution and kidney disease outcomes. This study adds to the growing epidemiological evidence that fine particles may impact distant organs (e.g., kidneys) over the short term.
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spelling pubmed-83670532021-08-18 Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area Bi, Jianzhao Barry, Vaughn Weil, Ethel J. Chang, Howard H. Ebelt, Stefanie Environ Epidemiol Original Research Article Toxicological evidence has shown that fine particulate matter (PM(2.5)) may affect distant organs, including kidneys, over the short term. However, epidemiological evidence is limited. OBJECTIVES: We investigated associations between short-term exposure to PM(2.5), major PM(2.5) components [elemental carbon (EC), organic carbon (OC), sulfate, and nitrate], and gaseous co-pollutants (O(3), CO, SO(2), NO(2), and NO(x)) and emergency department (ED) visits for kidney diseases during 2002–2008 in Atlanta, Georgia. METHODS: Log-linear time-series models were fitted to estimate the acute effects of air pollution, with single-day and unconstrained distributed lags, on rates of ED visits for kidney diseases [all renal diseases and acute renal failure (ARF)], controlling for meteorology (maximum air and dew-point temperatures) and time (season, day of week, holidays, and long-term time trend). RESULTS: For all renal diseases, we observed positive associations for most air pollutants, particularly 8-day cumulative exposure to OC [rate ratio (RR) = 1.018, (95% confidence interval [CI]: 1.003, 1.034)] and EC [1.016 (1.000, 1.031)] per interquartile range increase exposure. For ARF, we observed positive associations particularly for 8-day exposure to OC [1.034 (1.005, 1.064)], EC [1.032 (1.002, 1.063)], nitrate [1.032 (0.996, 1.069)], and PM(2.5) [1.026 (0.997, 1.057)] per interquartile range increase exposure. We also observed positive associations for most criteria gases. The RR estimates were generally higher for ARF than all renal diseases. CONCLUSIONS: We observed positive associations between short-term exposure to fine particulate air pollution and kidney disease outcomes. This study adds to the growing epidemiological evidence that fine particles may impact distant organs (e.g., kidneys) over the short term. Lippincott Williams & Wilkins 2021-08-06 /pmc/articles/PMC8367053/ /pubmed/34414347 http://dx.doi.org/10.1097/EE9.0000000000000164 Text en Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Bi, Jianzhao
Barry, Vaughn
Weil, Ethel J.
Chang, Howard H.
Ebelt, Stefanie
Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title_full Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title_fullStr Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title_full_unstemmed Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title_short Short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the Atlanta metropolitan area
title_sort short-term exposure to fine particulate air pollution and emergency department visits for kidney diseases in the atlanta metropolitan area
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367053/
https://www.ncbi.nlm.nih.gov/pubmed/34414347
http://dx.doi.org/10.1097/EE9.0000000000000164
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