The nucleotide addition cycle of the SARS-CoV-2 polymerase

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Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and nsp8). We use a high-throughput magnetic-tweezers approach to develop...

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Detalles Bibliográficos
Autores principales: Bera, Subhas Chandra, Seifert, Mona, Kirchdoerfer, Robert N., van Nies, Pauline, Wubulikasimu, Yibulayin, Quack, Salina, Papini, Flávia S., Arnold, Jamie J., Canard, Bruno, Cameron, Craig E., Depken, Martin, Dulin, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367775/
https://www.ncbi.nlm.nih.gov/pubmed/34433083
http://dx.doi.org/10.1016/j.celrep.2021.109650
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