The Taxus genome provides insights into paclitaxel biosynthesis

The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total l...

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Detalles Bibliográficos
Autores principales: Xiong, Xingyao, Gou, Junbo, Liao, Qinggang, Li, Yanlin, Zhou, Qian, Bi, Guiqi, Li, Chong, Du, Ran, Wang, Xiaotong, Sun, Tianshu, Guo, Lvjun, Liang, Haifei, Lu, Pengjun, Wu, Yaoyao, Zhang, Zhonghua, Ro, Dae-Kyun, Shang, Yi, Huang, Sanwen, Yan, Jianbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367818/
https://www.ncbi.nlm.nih.gov/pubmed/34267359
http://dx.doi.org/10.1038/s41477-021-00963-5
Descripción
Sumario:The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of Taxus chinensis var. mairei with a total length of 10.23 gigabases. Taxus shared an ancestral whole-genome duplication with the coniferophyte lineage and underwent distinct transposon evolution. We discovered a unique physical and functional grouping of CYP725As (cytochrome P450) in the Taxus genome for paclitaxel biosynthesis. We also identified a gene cluster for taxadiene biosynthesis, which was formed mainly by gene duplications. This study will facilitate the elucidation of paclitaxel biosynthesis and unleash the biotechnological potential of Taxus.

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