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T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review
The occurrence of T–cell acute lymphoblastic leukemia (T–ALL), on a background of preexisting Philadelphia–negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367827/ https://www.ncbi.nlm.nih.gov/pubmed/34430196 http://dx.doi.org/10.1016/j.lrr.2021.100264 |
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author | Medawar, Georgio Ackula, Haritha Weinberg, Olga Roberts, Todd Meleveedu, Kapil |
author_facet | Medawar, Georgio Ackula, Haritha Weinberg, Olga Roberts, Todd Meleveedu, Kapil |
author_sort | Medawar, Georgio |
collection | PubMed |
description | The occurrence of T–cell acute lymphoblastic leukemia (T–ALL), on a background of preexisting Philadelphia–negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred de-novo or were due to the clonal progression of underlying MPN. We present a case of a 49–year-old man with a history of essential thrombocythemia who subsequently developed T–ALL. By utilizing next generation sequencing we were able to determine that these two entities originated from two distinct clones and were likely random events. We report the outcome and review the literature. |
format | Online Article Text |
id | pubmed-8367827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83678272021-08-23 T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review Medawar, Georgio Ackula, Haritha Weinberg, Olga Roberts, Todd Meleveedu, Kapil Leuk Res Rep Article The occurrence of T–cell acute lymphoblastic leukemia (T–ALL), on a background of preexisting Philadelphia–negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred de-novo or were due to the clonal progression of underlying MPN. We present a case of a 49–year-old man with a history of essential thrombocythemia who subsequently developed T–ALL. By utilizing next generation sequencing we were able to determine that these two entities originated from two distinct clones and were likely random events. We report the outcome and review the literature. Elsevier 2021-08-10 /pmc/articles/PMC8367827/ /pubmed/34430196 http://dx.doi.org/10.1016/j.lrr.2021.100264 Text en © 2021 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Medawar, Georgio Ackula, Haritha Weinberg, Olga Roberts, Todd Meleveedu, Kapil T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title | T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title_full | T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title_fullStr | T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title_full_unstemmed | T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title_short | T–cell Acute Lymphoblastic Leukemia in a Patient with Pre–existing Essential Thrombocythemia: A Case Report and Literature Review |
title_sort | t–cell acute lymphoblastic leukemia in a patient with pre–existing essential thrombocythemia: a case report and literature review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367827/ https://www.ncbi.nlm.nih.gov/pubmed/34430196 http://dx.doi.org/10.1016/j.lrr.2021.100264 |
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