Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis

ABSTRACT: Arming of oncolytic viruses with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown as a viable approach to increase the antitumor efficacy in melanoma. However, melanoma cells may be partially or completely resistant to TRAIL or develop TRAIL resistance, thus c...

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Detalles Bibliográficos
Autores principales: Tolksdorf, Beatrice, Zarif, Sina, Eberle, Jürgen, Hazini, Ahmet, Dieringer, Babette, Jönsson, Franziska, Kreppel, Florian, Kurreck, Jens, Fechner, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367928/
https://www.ncbi.nlm.nih.gov/pubmed/34028599
http://dx.doi.org/10.1007/s00109-021-02081-3

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