Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM)

BACKGROUND: Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A (lysine-specific histone demethylase 4) was overe...

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Detalles Bibliográficos
Autores principales: Lapidot, Moshe, Case, Abigail E., Weisberg, Ellen L., Meng, Chengcheng, Walker, Sarah R., Garg, Swati, Ni, Wei, Podar, Klaus, Hung, Yin P., Carrasco, Ruben D., Knott, Aine, Gokhale, Prafulla C., Sharma, Sunil, Pozhitkov, Alex, Kulkarni, Prakash, Frank, David A., Salgia, Ravi, Griffin, James D., Saladi, Srinivas V., Bueno, Raphael, Sattler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368004/
https://www.ncbi.nlm.nih.gov/pubmed/34088988
http://dx.doi.org/10.1038/s41416-021-01441-7

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