Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A

Nephrotic syndrome (NS) is a common kidney disorder caused by dysfunction of the glomerular filtration barrier. Some genetic mutations identified in NS patients cause amino acid substitutions of kidney ankyrin repeat-containing (KANK) proteins, which are scaffold proteins that regulate actin polymer...

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Detalles Bibliográficos
Autores principales: Xu, Yuqun, Guo, Chen, Pan, Wenfei, Zhao, Chan, Ding, Yanyan, Xie, Xingqiao, Wei, Zhiyi, Sun, Ying, Yu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368038/
https://www.ncbi.nlm.nih.gov/pubmed/34274317
http://dx.doi.org/10.1016/j.jbc.2021.100958

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