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Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core

The processes underlying formation and growth of unfolded protein inclusions are relevant to neurodegenerative diseases but poorly characterized in living cells. In S. cerevisiae, inclusions formed by mutant huntingtin (mHtt) have some characteristics of biomolecular condensates but the physical nat...

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Detalles Bibliográficos
Autores principales:	Pei, Sen, Swayne, Theresa C., Morris, Jeffrey F., Emtage, Lesley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368079/ https://www.ncbi.nlm.nih.gov/pubmed/34400761 http://dx.doi.org/10.1038/s42003-021-02460-z

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