Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability

Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships be...

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Autores principales: Shen, Xinyi, Li, Lihua, Sun, Zhen, Zang, Guangyao, Zhang, Lili, Shao, Chen, Wang, Zhongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368126/
https://www.ncbi.nlm.nih.gov/pubmed/34414217
http://dx.doi.org/10.3389/fcvm.2021.668532
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author Shen, Xinyi
Li, Lihua
Sun, Zhen
Zang, Guangyao
Zhang, Lili
Shao, Chen
Wang, Zhongqun
author_facet Shen, Xinyi
Li, Lihua
Sun, Zhen
Zang, Guangyao
Zhang, Lili
Shao, Chen
Wang, Zhongqun
author_sort Shen, Xinyi
collection PubMed
description Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites.
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spelling pubmed-83681262021-08-18 Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability Shen, Xinyi Li, Lihua Sun, Zhen Zang, Guangyao Zhang, Lili Shao, Chen Wang, Zhongqun Front Cardiovasc Med Cardiovascular Medicine Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events. Recently, many studies have demonstrated that there are some relationships between microbiota and atherosclerosis. In this review, we will focus on the effect of the microbiota and the microbe-derived metabolites, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs), and lipopolysaccharide (LPS), on the stability of atherosclerotic plaque. Finally, we will conclude with some therapies based on the microbiota and its metabolites. Frontiers Media S.A. 2021-08-03 /pmc/articles/PMC8368126/ /pubmed/34414217 http://dx.doi.org/10.3389/fcvm.2021.668532 Text en Copyright © 2021 Shen, Li, Sun, Zang, Zhang, Shao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Shen, Xinyi
Li, Lihua
Sun, Zhen
Zang, Guangyao
Zhang, Lili
Shao, Chen
Wang, Zhongqun
Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title_full Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title_fullStr Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title_full_unstemmed Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title_short Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability
title_sort gut microbiota and atherosclerosis—focusing on the plaque stability
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368126/
https://www.ncbi.nlm.nih.gov/pubmed/34414217
http://dx.doi.org/10.3389/fcvm.2021.668532
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