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Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England

BACKGROUND: Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available. METHODS: We analysed data from the National Cancer Registration and Analysis Service on women diagnosed with invasive breast c...

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Autores principales: Gathani, Toral, Reeves, Gillian, Broggio, John, Barnes, Isobel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368149/
https://www.ncbi.nlm.nih.gov/pubmed/34040176
http://dx.doi.org/10.1038/s41416-021-01409-7
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author Gathani, Toral
Reeves, Gillian
Broggio, John
Barnes, Isobel
author_facet Gathani, Toral
Reeves, Gillian
Broggio, John
Barnes, Isobel
author_sort Gathani, Toral
collection PubMed
description BACKGROUND: Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available. METHODS: We analysed data from the National Cancer Registration and Analysis Service on women diagnosed with invasive breast cancer during 2013–2018. Multivariable logistic regression yielded adjusted odds ratios (and 95% confidence intervals) of less favourable tumour characteristics (high stage, high grade, ER negative, Her2 positive) by ethnicity (black African, black Caribbean, Indian, Pakistani and white) in younger (30–46 years) and older (53–70 years) women. RESULTS: In 24,022 women aged 30–46 at diagnosis, all ethnic minority groups apart from Indian women had a significantly greater odds of certain less favourable tumour characteristics compared to white women in fully adjusted models. In 92,555 women aged 53–70, all ethnic minorities had a significantly greater adjusted odds of several of the less favourable tumour characteristics. These differences were most marked in black African and black Caribbean women. CONCLUSIONS: Ethnic minority women are at greater risk of breast cancers with less favourable characteristics, even after allowing for age and other potential confounders. These differences are greater in older than younger women, and in the Black rather than South Asian ethnic groups.
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spelling pubmed-83681492021-08-31 Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England Gathani, Toral Reeves, Gillian Broggio, John Barnes, Isobel Br J Cancer Article BACKGROUND: Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available. METHODS: We analysed data from the National Cancer Registration and Analysis Service on women diagnosed with invasive breast cancer during 2013–2018. Multivariable logistic regression yielded adjusted odds ratios (and 95% confidence intervals) of less favourable tumour characteristics (high stage, high grade, ER negative, Her2 positive) by ethnicity (black African, black Caribbean, Indian, Pakistani and white) in younger (30–46 years) and older (53–70 years) women. RESULTS: In 24,022 women aged 30–46 at diagnosis, all ethnic minority groups apart from Indian women had a significantly greater odds of certain less favourable tumour characteristics compared to white women in fully adjusted models. In 92,555 women aged 53–70, all ethnic minorities had a significantly greater adjusted odds of several of the less favourable tumour characteristics. These differences were most marked in black African and black Caribbean women. CONCLUSIONS: Ethnic minority women are at greater risk of breast cancers with less favourable characteristics, even after allowing for age and other potential confounders. These differences are greater in older than younger women, and in the Black rather than South Asian ethnic groups. Nature Publishing Group UK 2021-05-26 2021-08-17 /pmc/articles/PMC8368149/ /pubmed/34040176 http://dx.doi.org/10.1038/s41416-021-01409-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gathani, Toral
Reeves, Gillian
Broggio, John
Barnes, Isobel
Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title_full Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title_fullStr Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title_full_unstemmed Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title_short Ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in England
title_sort ethnicity and the tumour characteristics of invasive breast cancer in over 116,500 women in england
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368149/
https://www.ncbi.nlm.nih.gov/pubmed/34040176
http://dx.doi.org/10.1038/s41416-021-01409-7
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