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Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix

Human ATP-dependent Lon protease (LONP1) forms homohexameric, ring-shaped complexes. Depletion of LONP1 causes aggregation of a broad range of proteins in the mitochondrial matrix and decreases the levels of their soluble forms. The ATP hydrolysis activity, but not protease activity, of LONP1 is cri...

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Detalles Bibliográficos
Autores principales:	Matsushima, Yuichi, Takahashi, Kazuya, Yue, Song, Fujiyoshi, Yuki, Yoshioka, Hideaki, Aihara, Masamune, Setoyama, Daiki, Uchiumi, Takeshi, Fukuchi, Satoshi, Kang, Dongchon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368198/ https://www.ncbi.nlm.nih.gov/pubmed/34400774 http://dx.doi.org/10.1038/s42003-021-02498-z

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