Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach

Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.

Detalles Bibliográficos
Autores principales: Lauder, Sarah N., Vanhaesebroeck, Bart, Gallimore, Awen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368216/
https://www.ncbi.nlm.nih.gov/pubmed/33824480
http://dx.doi.org/10.1038/s41416-021-01285-1
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author Lauder, Sarah N.
Vanhaesebroeck, Bart
Gallimore, Awen
author_facet Lauder, Sarah N.
Vanhaesebroeck, Bart
Gallimore, Awen
author_sort Lauder, Sarah N.
collection PubMed
description Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.
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spelling pubmed-83682162021-08-31 Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach Lauder, Sarah N. Vanhaesebroeck, Bart Gallimore, Awen Br J Cancer Comment Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice. Nature Publishing Group UK 2021-04-06 2021-08-17 /pmc/articles/PMC8368216/ /pubmed/33824480 http://dx.doi.org/10.1038/s41416-021-01285-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Lauder, Sarah N.
Vanhaesebroeck, Bart
Gallimore, Awen
Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title_full Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title_fullStr Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title_full_unstemmed Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title_short Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach
title_sort sequential targeting of pi3kδ and lag3 as an effective anti-cancer approach
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368216/
https://www.ncbi.nlm.nih.gov/pubmed/33824480
http://dx.doi.org/10.1038/s41416-021-01285-1
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